鼠尾藻的化学成分研究

江茜, 刘东, 杨加波, 严鹏程, 黄可新, 林文翰

中国药学杂志 ›› 2012, Vol. 47 ›› Issue (12) : 948-952.

中国药学杂志
中国药学杂志 ›› 2012, Vol. 47 ›› Issue (12) : 948-952.
论著

鼠尾藻的化学成分研究

  • 江茜1，刘东2，杨加波3，严鹏程1，黄可新1*，林文翰2*
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Chemical Constituents from Marine Alga Sargassum thunbergii

  • JIANG Qian1，LIU Dong 2，YANG Jia-bo 3，YAN Peng-cheng1，HUANG Ke-xin 1*，LIN Wen-han2*
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文章历史 +

摘要

目的 研究鼠尾藻的化学成分。方法 采用正相及反相硅胶柱色谱、Sephadex LH-20凝胶柱色谱、半制备高效液相色谱等方法进行分离纯化，根据理化性质及波谱学数据鉴定化合物的结构。结果 从鼠尾藻乙醇提取物中，分离鉴定了15个化合物，其中9个异戊二烯类化合物，分别为黑麦草内酯（1），异黑麦草内酯（2），loliolide acetate（3），蚱蜢酮（4），apo-9′-fucoxanthinone（5），3α-hydroxy-5，6-epoxy-7-megastigmen-9-one（6），deacetylate-apo-13′-fucoxanthinone（7），apo-13′-fucoxanthinone（8），(R)-(-)-3-羟基-β-紫罗兰酮（9），6个其他类型的化合物，sargassum ketone（10），2-heptenoic acid-4，4-dihydroxy-2，3-dimethyl-γ-lactone（11），(R)-2-hydroxy-3-phenylpropanamide（12），脱氧核糖胸腺嘧啶（13），岩藻甾醇（14），甘油脂肪酸酯（15）。结论 deacetylate-apo-13′-fucoxanthinone (7) 为新化合物，化合物3，5，6，8，9，15为首次从该属植物中分离得到。

Abstract

OBJECTIVE To study the chemical constituents of Sargassum thunbergii. METHODS The compounds were isolated and purified upon extensive column chromatography using silica gel，ODS，Sephadex LH-20，and prepative HPLC，while their structures were identified on the basis of physicochemical properties and spectroscopic data analysis. RESULTS Fifteen compounds were isolated from the EtOH extract. The structures were identified as (+)-isololiolide (1)，(-)-loliolide(2)，loliolide acetate(3)，grasshopper ketone(4)，apo-9′-fucoxanthinone(5)，3α-hydroxy-5，6-epoxy-7-megastigmen-9-one(6)，deacetylate-apo-13′-fucoxanthinone (7)，apo-13′-fucoxanthinone(8)，(R)-(-)-3-hydroxy-β-ionone(9) and 6 other compounds sargassum ketone(10)，2-heptenoicacid，4，4-dihydroxy-2，3-dimethyl-γ-lactone (11)，(R)-2-hydroxy-3-phenylpropanamide(12)，thymidine(13)，fucosterol(14) and hexadecanoic acid-2′，3′-dihydroxypropyl ester(15). CONCLUSION Deacetylate-apo-13′-fucoxanthinone is a new compound，and compounds 3，5，6，8，9，15 are obtained from the genus Sargassum for the first time.

关键词

鼠尾藻 / 异戊二烯类 / deacetylate-apo-13′-fucoxanthinone / loliolide acetate / apo-9′-fucoxanthinone / 3α-hydroxy-5 / 6-epoxy-7-megastigmen-9-one / apo-13′-fucoxanthinone / (R)-(-)-3-羟基-β-紫罗兰酮 / 甘油脂肪酸酯

Key words

Sargassum thunbergii / isoprene / deacetylate-apo-13′-fucoxanthinone / loliolide acetate / apo-9′-fucoxanthinone / 3α-hydroxy-5 / 6-epoxy-7-megastigmen-9-one / apo-13′-fucoxanthinone / (R)-(-)-3-hydroxy-β-ionone / hexadecanoic acid-2′ / 3′-dihydroxypropyl ester

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江茜, 刘东, 杨加波, 严鹏程, 黄可新, 林文翰. 鼠尾藻的化学成分研究[J]. 中国药学杂志, 2012, 47(12): 948-952
JIANG Qian, LIU Dong, YANG Jia-Bo, YAN Peng-Cheng, HUANG Ke-Xin, LIN Wen-Han. Chemical Constituents from Marine Alga Sargassum thunbergii[J]. Chinese Pharmaceutical Journal, 2012, 47(12): 948-952
中图分类号： R284.1   

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基金

基金项目：国家科技重大专项课题（2009ZX09501-014）

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