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�й�ҩѧ��־ 2012, Vol. 22 Issue (9) :669-672    DOI:
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XU Yan��jie1��SHI Xian��feng1��YANG Xiao��wen1��LIU Xiao��hong1��CHEN Yi2��QIU Li��xia1*
(1��Department of Health Statistics�� Shanxi Medical University�� Taiyuan 030001�� China�� 2�� College of Mechanical and Electrical Engineering �� University of Electronic Science and Technology of China��Chengdu 610054�� China)����

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ժҪ Ŀ���о���Ŀ���Ŵ��㷨��MOGA����΢����ȡ��ζ����ȡ���������е�Ӧ�ã�������Ч���������ۡ���������ζ����ȡ���վ������ʵ�����ݽ����Խ�����ʡ���ζ�Ӵ��׺���ľ֬�ص���Ŀ��ģ�ͣ����ö�Ŀ���Ŵ��㷨������ж�Ŀ���Ż�������������ȡ�������Ƚ��������������Matlab2009a���SGALAB������beta5008����Ŵ��㷨��Ѱ�ţ�����SPSS13��0�������ͳ�Ʒ���������õ������Ź�������Ϊ΢������270 W���Ҵ��������Ϊ87%����ȡʱ��Ϊ7 min���Ҵ�����Ϊ1�á�DK����4��5����Ƭ�����Ϊ70Ŀ���������µ���������������Ϊ21��40%����ζ�Ӵ���4��72%����ζ����ľ֬��10��84%�����۶�Ŀ���Ŵ��㷨������Pareto���ӽ��ڱ�֤��Ŀ�궼���ŵ�ǰ�����DZȽ�����ģ�Ϊ��ζ�ӵ���������ѡ���ṩ�˺���ķ��������ƹ㵽����ҩ�����������ѡ�񡣪�
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Abstract�� ABSTRACT��OBJECTIVE To study the application of Multi��objective Genetic Algorithm in optimization of micro��extraction technology of Schisandrae Chinensis Fructus�� METHODS Sub��target model of extraction rate�� schizandrin and the total lignan was established based on micro��extraction Schisandrae Chinensis Fructus experimental data resulted from uniform design�� Applying MOGA�� the optimal extracting conditions were explored�� and the results were compared with those of Single��objective genetic algorithm�� Using SGALAB beta5008 of the Matlab2009a plug��in tool��box��  the genetic algorithm optimization was achieved�� SPSS13��0 software was used for statistical analysis�� RESULTSThe optimal conditions were as follows�� microwave power 270 W�� ethanol 87%�� extraction time 7 min�� ethanol amount 1�� 4��5�� grinding degree 70�� Under these conditions�� the extract rate was 21��40%�� Schizandrin recovery was 4��72%�� and the total lignan recovery was 10��84%�� CONCLUSIONMOGA provides a reasonable pareto ensuring the optimal multi��objective�� which provides a reasonable method for extraction of Schisandrae Chinensis Fructus�� This method can be applied in the selection of extraction technology of other drugs��
Keywords�� Schisandrae Chinensis Fructus�� extraction technology�� uniform design�� genetic algorithm�� multi��objective optimization�� ,   Pareto non��inferior solution�� schizandrin�� thetotal lignan     
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.��Ŀ���Ŵ��㷨�Ż���ζ����ȡ���յ��о�[J]  �й�ҩѧ��־, 2012,V22(9): 669-672
.Optimization of Extraction Technology of Schisandrae Chinensis Fructus  by Multi��objective Genetic Algorithm����[J]  Chinese Pharmaceutical Journal, 2012,V22(9): 669-672
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