(1Department of Health Statistics， Shanxi Medical University， Taiyuan 030001， China； 2 College of Mechanical and Electrical Engineering ， University of Electronic Science and Technology of China，Chengdu 610054， China)
ABSTRACT：OBJECTIVE To study the application of Multiobjective Genetic Algorithm in optimization of microextraction technology of Schisandrae Chinensis Fructus METHODS Subtarget model of extraction rate， schizandrin and the total lignan was established based on microextraction Schisandrae Chinensis Fructus experimental data resulted from uniform design Applying MOGA， the optimal extracting conditions were explored， and the results were compared with those of Singleobjective genetic algorithm Using SGALAB beta5008 of the Matlab2009a plugin toolbox， the genetic algorithm optimization was achieved SPSS130 software was used for statistical analysis RESULTSThe optimal conditions were as follows： microwave power 270 W， ethanol 87%， extraction time 7 min， ethanol amount 1∶ 45， grinding degree 70 Under these conditions， the extract rate was 2140%， Schizandrin recovery was 472%， and the total lignan recovery was 1084% CONCLUSIONMOGA provides a reasonable pareto ensuring the optimal multiobjective， which provides a reasonable method for extraction of Schisandrae Chinensis Fructus This method can be applied in the selection of extraction technology of other drugs
XU Yanjie;SHI Xianfeng;YANG Xiaowen;LIU Xiaohong;CHEN Yi;QIU Lixia.
Optimization of Extraction Technology of Schisandrae Chinensis Fructus by Multiobjective Genetic Algorithm[J]. Chinese Pharmaceutical Journal, 2012, 47(9): 669-672
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