(1��Department of Health Statistics�� Shanxi Medical University�� Taiyuan 030001�� China�� 2�� College of Mechanical and Electrical Engineering �� University of Electronic Science and Technology of China��Chengdu 610054�� China)����
Abstract��
ABSTRACT��OBJECTIVE To study the application of Multi��objective Genetic Algorithm in optimization of micro��extraction technology of Schisandrae Chinensis Fructus�� METHODS Sub��target model of extraction rate�� schizandrin and the total lignan was established based on micro��extraction Schisandrae Chinensis Fructus experimental data resulted from uniform design�� Applying MOGA�� the optimal extracting conditions were explored�� and the results were compared with those of Single��objective genetic algorithm�� Using SGALAB beta5008 of the Matlab2009a plug��in tool��box�� the genetic algorithm optimization was achieved�� SPSS13��0 software was used for statistical analysis�� RESULTSThe optimal conditions were as follows�� microwave power 270 W�� ethanol 87%�� extraction time 7 min�� ethanol amount 1�� 4��5�� grinding degree 70�� Under these conditions�� the extract rate was 21��40%�� Schizandrin recovery was 4��72%�� and the total lignan recovery was 10��84%�� CONCLUSIONMOGA provides a reasonable pareto ensuring the optimal multi��objective�� which provides a reasonable method for extraction of Schisandrae Chinensis Fructus�� This method can be applied in the selection of extraction technology of other drugs��
.Optimization of Extraction Technology of Schisandrae Chinensis Fructus by Multi��objective Genetic Algorithm����[J] Chinese Pharmaceutical Journal, 2012,V22(9): 669-672
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