Abstract��
OBJECTIVE To study the pharmacokinetics of picamilon tablet in 12 healthy volunteers. METHODS Picamilon tablets were administrated to healthy volunteers, and plasma concentrations were determined by LC-MS. The pharmacokinetic parameters were calculated. RESULTS The oral dose of 50, 100 and 200 mg were administrated to volunteers. The pharmacokineitc parameters were as follows: tmax (0.73��0.41), (0.67��0.33) and (0.67��0.31)h, t1/2 (0.68��0.22), (0.89��0.41) and (0.91��0.21)h, ��max (1 328.75��552.33), (2 460.83��571.19) and (4 415.00��1 077.45) ��g��L-1, AUC0-tn (1 617.37��575.48), (3 117.08��620.93) and (5 987.01��1 365.57) ��g��h��L-1, AUC0-�� (1 697.45��584.78), (3 227.39��641.54) and (6 192.36��1 388.59) ��g��h��L-1, respectively. The plasma concentration-time curves were described by a two compartment open model. CONCLUSION ��AUC and ��max could be increased with the increased dose. No gender effect on pharmacokinetic parameters was found.
JIA Li-hua,
HAO Guang-tao,
GAO Hong-zhi etc
. Pharmacokinetics of Picamilon Tablet in Healthy Volunteers[J] Chinese Pharmaceutical Journal, 2009,V44(23): 1818-1820
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[1]
LI Z H, HE H X, HAN M, et al. Pharmacokinetics of domestic nimodipin capsule in healthy volunteers[J]. China Pharmacy ( �й�ҩ�� ),2003,14(1):31-32.
[2]
SUN H Y �� HAN J. Determination of the content and the related substances of picamilon injection by HPLC[J]. Qilu Pharm Aff ( ��³ҩ�� ), 2008, 27(2): 90-91.
2009, Vol. 44 