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�й�ҩѧ��־ 2012, Vol. 47 Issue (5) :347-350     DOI:
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����ҽѧԺ��������ҽԺҩ���ƣ����� 510150
Department of Pharmacy�� The Third Affiliated Hospital of Guangzhou Medical College�� Guangzhou 510150�� China

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ժҪ Ŀ�� ̽�ֵ�յ���ض�A��42�յ������ĺ�Ĭ��(AD)����ģ��ѧϰ���书�ܼ�������������Ӱ�졣���� ���ò�����ע��A��42 �ķ����Ʊ�����մ�ģ�ͣ� �������Ϊ5�飬�������������Ϊ�����飬ˮ�Թ�ʵ����Դ���ѧϰ���������ı仯�����÷ֹ��ȷ��ⶨ����֯�й��׸��Ĺ�������ø(GSH-Px)�����������绯ø(SOD)���Ժͱ���ȩ(MDA)�ĺ�������� Morrisˮ�Թ�ʵ����ʾ��ģ��������ӱ�DZ���ڽ������������ӳ���ԭ����ͣ��ʱ���������̡���յ����������ӱ�DZ���ڽ�ģ�����������̣�ԭ����ͣ��ʱ�������ӳ���ģ�����������֯GSH-Px��SOD�����½���MDA�����������ࣻ��յ����������ѧϰ�ͼ����������ߣ�����֯GSH-Px��SOD�������ߣ�MDA�������٣���ģ����Ƚ��������Բ��졣���� ��յ���ض�ADģ�ʹ���ѧϰ�����ϰ��������Ը������ò��ҿɼ��������Ե���������ADģ�ʹ���Ŀ�����������
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Abstract�� OBJECTIVE To study the effect of breviscapine on memory and antioxidation ability in A��42-induced Alzheimer��s disease (AD) rat model. METHODS AD rat model was established by intracerebroventricular injection of A��42. Besides�� sham-operated mice served as control group. The learning and memory ability was determined by Morris water maze test. The activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) and the content of Malondialdehyde (MDA) in brain tissue were measured with spectrophotometer. RESULTS Compared with control group�� AD model significantly prolonged the latency of searching the hidden platform in directional swimming test�� and decreased time spent in swimming in the target quadrant in probe test. Breviscapine dose-dependently shortened the latency of searching the hidden platform in directional swimming test�� and increased the time spent swimming in the target quadrant in probe test. The activities of GSH-Px and SOD were decreased�� and the MDA content was increased in AD model rats.In breviscapine treatment groups�� the activities of GSH-Px and SOD heightened and MDA content decreased�� and there was significant difference compared with AD model group. CONCLUSION Breviscapine can dose-dependently ameliorate the impaired learning and memory function of AD model rats and improve antioxidation ability.
Keywords�� breviscapine,   Alzheimer��s disease,   learning and memory,   oxidative stress     
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.��յ���ض԰����ĺ�Ĭ��ģ�ʹ���ѧϰ����Ϳ�����������Ӱ��[J]  �й�ҩѧ��־, 2012,V47(5): 347-350
.Influence of Breviscapine on Memory and Antioxidation Ability in Rats with Alzheimer��s Disease[J]  Chinese Pharmaceutical Journal, 2012,V47(5): 347-350
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