Key Laboratory of Clinical Trial Research in Cardiovascular Drugs�� Ministry of Health�� Cardiovascular Institute and Fuwai Hospital�� Peking Union Medical College and Chinese Academy of Medical Science�� Beijing 10037�� China
Abstract��
OBJECTIVE To evaluate the effect of amiodarone on warfarin initial anticoagulation response within the first week in the patients with heart valve replacement. METHODS The differences in the total warfarin dose of the first 5 d�� INR within the therapeutic window in day 6 and the time to first INR in therapeutic range after operation were compared between the patients who took warfarin only and combining use of amiodarone. RESULTS The total warfarin dose of the first 5 d was lower in warfarin group than that of warfarin and amiodarone group. The combining use of amiodarone was not associated with INR within the therapeutic window in day 6 after operation and the time to first INR in therapeutic range. CONCLUSION Amiodarone does not affect the initial anticoagulation response of warfarin within the first week in patients with heart valve replacement.
.Effects of Amiodarone Dose on the Initial Anticoagulation Response of Warfarin Within 1 Week in Patients with Heart Valve Replacement[J] Chinese Pharmaceutical Journal, 2010,V45(8): 593-596
2010, Vol. 45 
