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�й�ҩѧ��־ 2010, Vol. 45 Issue (13) :991-996    DOI:
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ZENG Ai-guo1�� WANG Chang-he2�� WANG Lei1��FU Qiang1*

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ժҪ Ŀ�� ���찱�ȵ�ƽ��AML�������ջ��ƣ����о��������ȵ�ƽ��S-AML������������(RS-AML)�ڴ��󳦵����յIJ����ԡ����� Ӧ�����峦ѭ��ģ�ͣ�����HPLC�ⶨS-AML��RS-AML�ڳ�ѭ��Һ�е�����Ũ�ȱ仯����� ��ѭ��Һ��S-AML����RS-AML������Ũ��Ϊ1��4��8 ��g��mL-1ʱ��S-AML����RS-AML�����������ʳ�����ka����t1/2���������Բ��죨P>0.05����S-AML����RS-AML���ڴ�������ε�ka��t1/2���������Բ��죨P>0.05����S-AML��RS-AML���ߵ�ka����t1/2���ڴ���������������Բ���(P>0.05)���ڳ�ѭ��Һ�м���P-�ǵ��ף�P-gp�����Ƽ�ά�����׺�S-AML��RS-AML��ka��t1/2������������(P<0.05)��������֮���������Բ���(P>0.05)�� ���� S-AML��RS-AML�ڴ����Ĥ����Ҫת�˻���Ϊ������ɢ���̣����������մ��ڣ�S-AML��RS-AML�����ڴ�������ε������޲��죻AML�ڳ��Ĥ��ת��������ѡ���ԡ�
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Abstract�� OBJECTIVE To investigate the absorptive difference between S-amlodipine (S-AML) and RS-amlodipine (RS-AML) in rat intestine as well as the mechanism of the absorption of AML. METHODS In situ recirculation model was used and the concentration of RS-AML or S-AML in the recirculate was determined by HPLC. RESULTS The absorption rate constant (ka) and t1/2 of S-AML (or RS-AML) had no significant difference (P> 0.05) at concentration of 1�� 4 and 8 ��g��mL-1. The ka and t1/2 of S-AML (or RS-AML) in three different regions of rat intestine (duodenum�� jejunum�� and ileum) had no significant difference (P> 0.05). The ka (or t1/2) of S-AML and RS-AML in three different regions of intestine of rat had no significant difference (P> 0.05). The ka and t1/2 of RS-AML (or S-AML) were obviously increased when verapamil was co-perfused with AML�� but the ka (or t1/2) of RS-AML and S-AML had no significant difference (P> 0.05). CONCLUSION The absorption of RS-AML or S-AML in rat intestine showed the passive diffusion process�� and without a special absorption region. There was no the absorptive difference between S-AML and RS-AML in rat intestine. There was no intrinsic enantioselectivity in absorption of AML.
Keywords�� amlodipine,   S-amlodipine,   in situ single recirculation model,   absorption     
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.�������ȵ�ƽ�����������ڴ��󳦵������ղ������о�[J]  �й�ҩѧ��־, 2010,V45(13): 991-996
.Study on Absorptive Difference between S-Amlodipine and RS-Amlodipine in Rat Intestine[J]  Chinese Pharmaceutical Journal, 2010,V45(13): 991-996
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