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�й�ҩѧ��־ 2010, Vol. 45 Issue (21) :1671-1673    DOI:
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1. �й�ҽѧ��ѧԺ-����Э��ҽѧԺ�о���Ժ������ 100730��2.�����Ѻ�ҽԺ���ƣ�����100029��3.��������ҽԺ���ƣ����� 100050
YANG Ling1��2 �� HU Jing-wei1��2�� WANG Kun-di2�� ZHENG Cheng-ning2�� WANG Ping3�� ZHOU Zhong-shu2*
1.Graduate School of Peking Union Medical College�� Chinese Academy of Medical Science�� Beijing 100730�� China��2.Pediatrics Department of China-Japan Friendship Hospital�� Beijing 100029�� China��3.Pediatrics Department of Beijing Friendship Hospital�� Beijing 100050�� China

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ժҪ Ŀ�� �۲촨�鲡��Kawasaki�� KD�����ٴ��������������������򵰰ף�Intravenous Immunoglobulin�� IVIG������ǰ��ʵ���Ҽ��ı仯�Լ������������� ��29��KD�����ٴ����ϡ�ʵ���Ҽ������������лع��Է������ܽᡣ�ռ�ͬ��סԺ����24���Ǹ�Ⱦ������Ϊ�����飬��¼������ѪҺѧ������������KD����бȽϡ���� ��29��KD�����У�IVIG������25����IVIG�޷�Ӧ��4���������Ķ�ͼ�����ʾ����������16�����������ţ�Coronary Artery Dilation�� CAD��9������������Coronary Artery Aneurism�� CAA��4�������������Ƚϣ�����ǰKD����Ѫ��ϸ����Write Blood Cell�� WBC����������ϸ���ٷֱ�(neutrophilicgranulocyte�� N%���������ߣ��ܰ�ϸ���ٷֱȣ�lymphocyte��L%�����Խ��ͣ����ƺ�WBC��N%��L%�������Ƚ��������Բ��졣����KD��������ǰ�Ƚϣ����ƺ�WBC��N%�� C��Ӧ���ף�C-reactive protein��CRP�����Խ��ͣ�L%�������ߣ�Ѫ����Erythrocyte Sedimentation Rate ��ESR)�仯�����ԣ� ѪС�壨Blood Platelet��PLT����������Ӱ��������ߡ���22��KD���߽�����ã�12���������������·����䣬8��CAD��ȫ�ָ�������1��CAA������أ�1��CAA����ȫ�ָ������� �����IVIG����KDЧ�����⣬WBC��N%��L%��CRP�����ڻظ�������������Ϊ��Ӧ�����ڲ���仯��ָ�ꡣ��IVIG�޷�Ӧ��KD���������ӣ��Ա㼰ʱ��ȡ������Ч�����ƴ�ʩ��
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Abstract�� OBJECTIVE To study the clinic features�� changes of laboratory examination induced by intravenous immunoglobulin (IVIG) and follow-up results of Kawasaki disease (KD). METHODS The clinic information�� laboratory examination and follow-up results of 29 KD patients were reviewed. 24 non-infectious patients were assigned into control group�� and the laboratory examination result of controls was compared with KD group. RESULTS 25 of 29 KD patients were IVIG responders and 4 were IVIG non-responders. Echocardiography showed 16 cases of normal coronary artery�� 9 cases of coronary artery dilation (CAD)�� and 4 cases of coronary aneurysm (CAA). Before treatment�� WBC and the proportion of neutrophil (N%) in KD group were higher than those of controls�� while the proportion of lymphocytes(L%) was lower than that of control group. After treated by IVIG�� the WBC�� N% and L% returned to the control group level. In KD group�� after IVIG treatment�� WBC�� N% and CRP decreased significantly�� L% and PLT increased significantly�� ESR had no change. 22 KD patients were followed up. No new impairment occurred in 12 non-coronary artery lesion cases�� 8 CAD cases regressed completely�� 1 CAA extended�� the other CAA regressed incompletely. CONCLUSION IVIG is an effective agent in the treatment of KD�� WBC�� N%�� L% and CRP can be used to reflect conditions change in acute phase of KD. The doctors should pay attention to IVIG non-response KD in order to take active and effective treatment timely.
Keywords�� Kawasaki disease,   intravenous immunoglobulin,   IVIG non-response     
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.���������򵰰����ƴ��鲡���ٴ�����[J]  �й�ҩѧ��־, 2010,V45(21): 1671-1673
.Clinical Analysis of Intravenous Immunoglobulin in the Patients with Kawasaki Disease[J]  Chinese Pharmaceutical Journal, 2010,V45(21): 1671-1673
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