Abstract��
OBJECTIVE To compare the effects of magnesium and lidocaine with that of sufentanil for prevention of hypotension pre- endotracheal intubation or tachycardia and hypertension caused by endotracheal intubation. METHODS Eighty patients (aged 52-76 years�� weighing 49-87 kg�� ASA �� or �� EF��45% were randomized into four equal groups. Anesthesia was induced with midazolam 0.08 mg��kg-1�� and followed by sufentanil 0.6 ��g��kg-1 (group S1 or 0.9 ��g��kg-1 (group S2�� or sufentanil 0.6 ��g��kg-1 combined with magnesiun sulfate 20 mg��kg-1 (group MS or lidocaine 1.5 mg��kg-1 (group LS. Tracheal intubation was facilitated with vecuronium 0.12 mg��kg-1. Heart rate (HR and arterial pressure (SBP�� DBP and MAP were recorded before and after induction of anaesthesia�� immediately after intubation�� and 1�� 3�� 5�� and 8 min after intubation. RESULTS The four groups were comparable with respect to age�� sex�� body weight�� and duration of tracheal intubation. Compared with the other three groups�� SBP�� DBP and MAP decreased significantly in group S2 (P<0.05. While HR�� SBP�� DBP and MAP increased significantly in group S1 immediately after intubation and 1 min after intubation (P<0.05�� but the increase was less than that in other groups. In group S2 there was a significant decrease in arterial pressure 5 min after intubation�� but the decrease was less than that in other groups (P<0.05��P<0.01. More patients were treated due to tachycardia and hypertesion in group S1�� and hypotension in group S2. CONCLUSION Administration of magnesiun sulfate (20 mg��kg-1 or lidocaine (1.5 mg��kg-1 3 min before intubation can prevent tachycardia and arterial pressure increase caused by laryngoscopy and tracheal intubation�� and can be beneficial for stablizing hemodynamic parameters during anesthesia induction.
.Effects of Lidocaine and Magnesiun Sulfate on Hemodynamic Parameters During Anesthesia Induction in Patients with Coronary Artery Disease[J] Chinese Pharmaceutical Journal, 2011,V46(7): 557-558
2011, Vol. 46 
