中国药学杂志
    
           首页  |  期刊介绍  |  编 委 会  |  投稿指南  |  期刊订阅  |  广告服务  |  会议信息  |  联系我们  | 
�й�ҩѧ��־ 2011, Vol. 46 Issue (7) :527-531    DOI:
���� ����Ŀ¼ | ����Ŀ¼ | ������� | �߼����� << | >>
�����о��DZ��׻���ά�ض���΢�黯��ҩϵͳθ������Ϊ��Ӱ��
���1������1��2*����ӱ1��Ф�1���μ���3
1.���ϴ�ѧҩѧԺ������400715��2.���ſƼ���ѧ����ҩ�P����Ӧ���о���������000853��3.���ϴ�ѧ����Ƽ�ѧԺ������400715
HUAN Di1��2�� YI Tao1,2*�� LIU Yin1�� XIAO Lu1�� HE Ji-kui3
1.College of Pharmaceutical Sciences�� Southwest University�� Chongqing 400715�� China��2. Macau Institute for Applied Research in Medicine and Health�� Macau University of Science and Technology�� Macau 000853�� China��3.College of Animal Science and Technology�� Southwest University�� Chongqing 400715�� China

Download: PDF (1207KB)   HTML (0KB)   Export: BibTeX or EndNote (RIS)      Supporting Info
ժҪ Ŀ�� ̽���DZ��׻���ά�ض���΢�黯��ҩϵͳθ������Ϊ��Ӱ�죬Ϊ������΢�黯��ҩϵͳ�Ĺ�������ѡ���ṩ���ݡ����� ����θģ���ɢ���������֬��ģ�Ͳⶨ3�ֹ����DZ��׻���ά�أ�K4M��K15M��K100M����΢�黯��ҩϵͳθ������Ϊ��Ӱ�졣��� 3�ֹ����DZ��׻���ά�ض���������΢�黯��ҩϵͳ��θ�����еķ�ɢ���������DZ��׻���ά�ص������ӣ���΢�黯��ҩϵͳ����ҩ������ǿ��С��֬���������ˮ���ҩ��Ũ��Ҳ���ӡ����� �DZ��׻���ά����������΢�黯��ҩϵͳ��ҩ����θ���������գ�����Ϊ���ƹ�����΢�黯��ҩϵͳ�Ĺ������塣
Service
�ѱ����Ƽ�������
�����ҵ����
�������ù�����
Email Alert
RSS
�����������
�ؼ����� �DZ��׻���ά��   ��΢�黯��ҩϵͳ   ˮ������ҩ��   ��ɢ����   ����֬��ģ��     
Abstract�� OBJECTIVE To study the influence of different viscosity hydroxypropylmethylcellulose (HPMC on the digestion of self-microemulsifying drug delivery system (S-SMEDDS in the gastro-intestinal tract�� so as to provide basis for the further development of S-SMEDDS. METHODS In vitro experiments including dispersion experime nt and an in vitro lipolysis model were used to evaluate the influence of HPMC of three viscosity grade (K4M�� K15M and K100M on the digestion of S-SMEDDS in gastrointestinal tract. RESULTS All three kinds of HPMC could inhibit the precipitation of drug in gastro-intestinal tract. With the increasing of HPMC viscosity�� the solub drug concentration in aqueous phase after intestinal lipolysis were both increased. CONCLUSION HPMC can improve the gastrointestinal absorption of S-SMEDDS and be used as its solid carrier.
Keywords�� hydroxypropylmethylcellulose,   self-microemulsifying drug delivery systems,   poor soluble drugs,   dispersion tests,   in vitro lipolysis model     
�ո�����: 2011-11-11;
���ñ���:   
.�����о��DZ��׻���ά�ض���΢�黯��ҩϵͳθ������Ϊ��Ӱ��[J]  �й�ҩѧ��־, 2011,V46(7): 527-531
.Influence of Hydroxypropylmethylcellulose on Digestion of Self-Microemulsifying Drug Delivery System in Gastro-Intestinal Tract in Vitro[J]  Chinese Pharmaceutical Journal, 2011,V46(7): 527-531
��
û�б��IJο�����
Copyright 2010 by �й�ҩѧ��־