1. Applied Chemistry Research Institute Office of Wuhan University of Science and Technology��Wuhan 430081�� China��2.Jiujiang College of Chemistry and Chemical Engineering��Jiujiang 332005�� China��3. Medical College of Wuhan University of Science and Technology��Wuhan 430065�� China
Abstract��
ABSTRACT: OBJECTIVE To study the preparation of sofalcone alginate microcapsules and their in vitro release��MTTHODS Sofalcone microcapsules were prepared by emulsion method. The best preparation condition was determined by orthogonal experiment��The appearance of the microcapsules was observed by optical microscope, and the microcapsule size was measured by binocular inverted microscope�� Sofalcone content, encapsulation efficiency and recovery efficiency were determined using ultraviolet spectrophotometer.The embedding effect of microcapsules was proved by IR and X-ray diffraction. Besides, in viro release experiments were carried out in simulated intestinal fluid and gastric fluid��RESULTS At a stirring speed of 1 000 r��min-1, sodium alginate concentration of 3%, Span80 and Tween80 mass ratio of 2.5, andwater-oil volume ratio of 4 and core-wall ratio of 1��the microcapsules had good shape and smooth surface. The average encapsulation efficiency was 78.3%. The average drug loading was 5.54%, and the average particle size was 400 ��m�� The release of microcapsules in simulated intestinal fluid reached maximum value of 64% at 9 h,and remained stable thereafter, while in simulated gastric juice, the microcapsules achieved a smooth release of 8.5%. CONCLUSION Using sodium alginate as wall material microcapsules with good structure can be prepared by emulsion method. Theie in vitro release is in line with the in vivo effect��
2011, Vol. 46 
