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�й�ҩѧ��־ 2011, Vol. 46 Issue (17) :1356-1361    DOI:
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1. ������ѧҩѧԺ������100191��2. �׶�ҽ�ƴ�ѧ����������ǻҽԺ�о���������100050
YIN Qi-lei1�� LIU Yong1�� ZHAN Xian-wang1�� HAN Nan-yin1*�� LI Jin-lu2*�� YANG Sheng-hui2
1. School of Pharmaceutical Sciences�� Peking University�� Beijing 100191�� China; 2.Beijing Stomatological Hospital Institute�� Capital Medical University�� Beijing 100050�� China

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ժҪ Ŀ�� �о���ҩ������ȡ�MOCE��������Ҫ�ɷֺ��ӷ���ͺ��ӷӶ��ڳ�����ǻ�²���������𤸽��Ӱ�졣���� ѡȡ2����ȣ����2�����ܲ��²�����Ϊʵ����꣬�ñ���������Һϡ�ͷ��ֱ𿼲����4�ֿ�ǻ�²�������С�־�Ũ�ȣ�MIC������Сɱ��Ũ�ȣ�MBC����������ɱ�����ʣ�����𤸽ʵ��ģ�ͣ�����ҩ�������ȣ����𤸽�������ã���������γ�𤸽���Ѹ����á���� MOCE����4��ʵ������MIC��MBCֵ��С��100 ��g��mL-1�����Ҿ���ͻ������Чɱ���ص㣺1 mg��mL-1MOCE 30 s����Чɱ����99%���ϣ���MBCŨ���½�5 min ���ѱ��ֳ�����ɱ�����ã�>90%����������ȣ����𤸽���ƣ���С��ЧŨ��Ϊ6.25~25 ��g��mL-1������ֵIJ�ͬ����ͬ�����Ҹ�Ũ���¶����γɵ�𤸽�����Ѹ����á����� MOCE��4�ֿ�ǻ�²������������н�ǿ�������ã���Чɱ����������ȣ����𤸽���������γɺʹٽ��߽��˫Ч���ã��ڿ�ǻ��ҩ�ͱ������������Ҫ��ֵ��
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Abstract�� OBJECTIVE To evaluate the antimicrobial properties of Magnoliae officinalis��MOCE�� Cortex extract and its main components�� magnolol and honokiol against two cariogenic bacteria strains and two periodontal pathogens. METHODS The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) against each strain were determined by both cylinder-plate and broth-microdilution METHODS�� and bactericidal rate�� bacteria adhesion inhibition and bacteria desorption rates were measured by our experimental models. RESULTS The MIC and MBC of MOCE and its two main components against each strain were all less than 100 ��g��mL-1�� and the minimum effective concentrations for adhesion inhibition and desorption of two cariogenic bacteria were 6.25 and 25 ��g��mL-1�� respectively. Incubation of the bacteria with MOCE solution at 1 mg��mL-1 killed more than 99% of the test strains in 30 s. The extract at MBC against each strain also showed significant bacteriocidal effect in 5 min (>90%). CONCLUSION Our studies provided experimental evidence for further development and application of MOCE in the field of oral care.
Keywords�� Magnoliae officinalis Cortex,   cariogenic bacteria,   periodontal pathogens,   magnolol,   honokiol     
�ո�����: 2011-11-11;
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.������ȡ�����4�ֳ�����ǻ�²���������𤸽������[J]  �й�ҩѧ��־, 2011,V46(17): 1356-1361
.Evaluation of the Antimicrobial Properties of Magnoliae officinalis Cortex Extract and Its Main Components Against Four Oral Pathogenic Bacteria[J]  Chinese Pharmaceutical Journal, 2011,V46(17): 1356-1361
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