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�й�ҩѧ��־ 2011, Vol. 46 Issue (17) :1334-1339    DOI:
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���ᴨܺ�΢����͸������Ĥ��ɢ����ѧ�о����䴦���Ż�
�������������߳翭*
�㶫ҩѧԺҩ��ѧԺҩ�������ң����� 510006
LIU Li��LI Ning��GAO Chong-kai*
Department of Pharmaceutics��School of Pharmacy��Guangdong Pharmaceutical University��Guangzhou 510006�� China

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Abstract�� OBJECTIVE To deduce a modified empirical formula for predicting the release rate of drugs through different coating formulations of controlled porosity osmotic pump tablets ��CPOP�� using etramethylpyrazine phosphate ��TMPP�� as a model drug and to optimize the formulation of TMPP CPOP. METHODS The functions between drug release and coating formulation��film thickness and viscosity were studed by using free film diffusion equipment. Uniform design was adopted to optimize formulation. RESULTS Based on the theoretical formula and actual experimental data��the modified empirical formula which fit for controlled porosity osmotic pump tablets had been deduced. Regression equation and the best formulation were calculated by uniform design software. F test indicated that the regression equation was significant��and the linear correlation coefficient exceeded 0.99. CONCLUSION The modified empirical formula can accurately predict the drug diffusion rate in different conditions��thus it can provide useful information for further study. The cumulative release of the best formulation exceeds 90% at 12 h with good reproducibility and conforms to zero order rate.
Keywords�� tetramethlprazine phosphate ��TMPP��,   controlled porosity osmotic pump tablets ��CPOP��,   uniform design,   formula fitting,   formulation optimization     
�ո�����: 2011-11-11;
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.���ᴨܺ�΢����͸������Ĥ��ɢ����ѧ�о����䴦���Ż�[J]  �й�ҩѧ��־, 2011,V46(17): 1334-1339
.Study on Diffusion Kinetics of Tetramethylpyrazine Phosphate Through Free Coating Film of Controlled Porosity Osmotic Pump Tablets and Formulation Optimization[J]  Chinese Pharmaceutical Journal, 2011,V46(17): 1334-1339
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