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�й�ҩѧ��־ 2011, Vol. 46 Issue (22) :1762-1767    DOI:
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LIU Zhen1��2��3��TANG Hui-lin1��2��ZHAI Suo-di1��2*
1. Peking University Third Hospital, Beijing 100191,China��2.School of Pharmaceutical Sciences, Peking University Beijing 100191, China��3. Beijing Obstetrics and Gynecology Hospital of the Capital University of Medical Sciences, Beijing 100026, China

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ժҪ Ŀ�� ����������Զ����ѳ��ۺ������ߴ��������Ƶ���Ч�ԺͰ�ȫ�ԡ����� ����Pubmed��Embase��Cochraneϵͳ���ۺ��ٴ��������ݿ⣬CNKI���ռ��������������飬���������ۺ���RevMan5.1�������Meta��������� ������6������������飬��ΪӢ�����ס�Meta���������ʾ�������ʡ������ʡ������ʼ������¼������ʷ�������������������׷�֮��IJ�����ͳ��ѧ���壨1.15[0.86��1.54]��1.11[0.91��1.34]��1.45[0.52��4.08]��0��[-0.01��0.01]��������BMI��30�Ķ����ѳ��ۺ������ߣ������������Ч�����Ժ������������׷�[�����ʣ�RR=1.64,95%CI��1.08��2.50��]������ ����BMI��30�Ķ����ѳ��ۺ������ߣ����������ȡ�����������׷ҳ�Ϊһ�ߴ�����ҩ�������BMI��30�Ķ����ѳ��ۺ������ߣ������Բ���ָ�Ϸ������������ʽ�ĸ��ơ��������ܷ�������������׷ҳ�Ϊһ�ߴ�����ҩ��������ģ�ģ�������õ����������������֤��
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Abstract�� OBJECTIVE To assess the effectiveness and safety of letrozole (LE) for ovulation induction in women with PCOS. METHODS Pubmed, Embase, CNKI, and the Cochrane Library were searched. Randomized controlled trials of letrozole for ovulation induction in women with PCOS were collected. The quality of the retrieved trials was assessed, and meta-analyses were conducted using RevMan software 5.1. RESULTS Six RCTs were included, all of which were published in English. The RESULTS of Meta-analyses showed that there were no significant differences between letrozole and clomiphene Citrate in pregnancy rate, ovulation rate, miscarriage rate and adverse event incidence,��1.15[0.86��1.54]��1.11[0.91��1.34]��1.45[0.52��4.08]��0, [-0.01��0.01]��. For the patients with BMI��30, letrozole was more effective than clomiphene citrate in pregnancy rate [RR=1.64, 95%CI��1.08��2.50��]. CONCLUSION Letrozole can be considered as first-line treatment for ovulation induction for patients with BMI��30. According to the guideline, the lifestyle should be modified before treatment for patients with BMI��30. Due to insufficient evidence available in the literature, more large scale, good-designed RCTs are needed to confirm whether letrozole can be used as first-line drug.
Keywords�� letrozole,   clomiphene citrate ,   polycystic ovarian syndrome,   ovulation induction,   Meta analyses     
�ո�����: 2011-11-11;
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LIU Zhen, TANG Hui-lin, ZHAI Suo-di etc .Letrozole for Ovulation Induction in Women with Polycystic Ovarian Syndrome�� A Systematic Analysis[J]  Chinese Pharmaceutical Journal, 2011,V46(22): 1762-1767
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