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�й�ҩѧ��־ 2011, Vol. 46 Issue (24) :1948-1951    DOI:
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΢����ҩ����ҹ����о����ģ�������ҩ������ҩ�о������������ι�˾��ʯ��ׯ 050015
SHI Lei
National Engineering Research Center of Microbial Medicine�� New Drug R��D Co.Ltd of North China Pharmaceutical Group Co .Ltd��Shijiazhuang 050015�� China

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Abstract�� OBJECTIVE To establish a recovery process for mycophenolic acid from mother liquor of crude crystalline. METHODS First�� mycophenolic acid was transformed into the form of water-soluble salt by sodium hydroxide solution. Then mycophenolic acid was separated from the solution by macroporous resin D312. RESULTS The yield of transformation was over 90%. The overall yield of mycophenolic acid was increased by 10%�� and product��s quality met the standards. CONCLUSION This process has the advantages of high yield and low cost�� so it is satisfactory and provides a new thread for the industrial production of mycophenolic acid.
Keywords�� mycophenolic acid,   crystal-mother liquor,   recovery process     
�ո�����: 2011-11-11;
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ʯ��, ʯ�� .ù�����Ʒ�ᾧĸҺ���չ����о�[J]  �й�ҩѧ��־, 2011,V46(24): 1948-1951
SHI Lei, SHI Lei .Study on the Recovery Process of Mycophenolic Acid from Mother Liquor of Crude Crystalline[J]  Chinese Pharmaceutical Journal, 2011,V46(24): 1948-1951
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