目的 通过建立胃癌裸鼠种植瘤模型观察维生素（Vit）K₂联合苯那普利对人胃癌SGC-7901裸鼠种植瘤的影响，以探讨两者对胃癌细胞的作用及机制。方法 通过人胃癌SGC-7901细胞接种建立胃癌裸鼠种植瘤模型后，随机分成对照组、Vit K₂组、苯那普利组和联合组，每组10只，灌胃2周后处死；TUNEL法检测各组胃癌细胞凋亡情况，免疫组化法检测血管内皮生长因子（VEGF）、caspase 3的蛋白表达情况。结果 与对照组相比，药物组能明显抑制瘤体生长，而联合组较单独药物组抑制作用更明显(P

OBJECTIVE To investigate the effect of vitamin K₂ combined with benazepril on human gastric cancer in nude mice.METHODS SGC-7901 human gastric cancer cells were implanted into BALB/c nude mice to establish the cancer model. Fourteen days after the subcutaneous implantation of cancer cells，40 nude mice were randomly divided into 4 groups： control group， vitamin K₂ therapy group， benazepril therapy group and combination therapy group (vitamin K₂+ benazepril). After 14 d， the tumor growth was evaluated， apoptosis indices were examined by TUNEL assay， and VEGF and caspase 3 expression were assessed by immunohistochemical staining. RESULTS Compared to the control group， tumor weights were decreased and apoptosis indexes was significantly increased in the therapy groups (P