摘要
目的综述晚期糖基化终产物(advanced glycosylation endproducts,AGEs)的研究进展,评价AGEs途径作为药物作用靶点发现抗动脉粥样硬化药物的可能性。方法总结近年来国外具有代表性的文献,对AGEs作为药物作用靶点的可能性进行分析、归纳。结果AGEs不仅可通过与其他蛋白质发生交联,直接影响细胞和组织功能;而且与其特异受体的结合介导一系列病理反应,AGEs在组织和血液中的积聚导致糖尿病及其并发症、动脉粥样硬化、神经退行性疾病以及肾衰等多种疾病。结论AGEs抑制剂、AGEs裂解剂以及AGEs受体阻断剂极有可能成为新型的抗动脉粥样硬化以及相关的心血管疾病药物的候选化合物,将有非常好的应用前景。
关键词
晚期糖基化终产物 /
动脉粥样硬化 /
非酶糖基化
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方莲花;杜冠华.
晚期糖基化终产物和抗动脉粥样硬化药物发现策略[J]. 中国药学杂志, 2007, 42(11): 801-804
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脚注
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基金
国家自然科学基金资助项目(30572182)
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