Abstract��
OBJECTIVE To increase the transdermal ratio of ALA through its phospholipid compound(ALA-PC) which possesses enhanced lipophilicity.METHODS ALA-PC was prepared.The thermodynamics properties of ALA-PC were studied by DSC.Oil-water partition coefficient(PO/W),in vitro permeation and in vivo transdermal experiments were conducted to study the lipophilicity and transdermal properties of ALA-PC.RESULTS A compound ratio of 99.6% was obtained.Some new peaks appeared in the DSC spectra of ALA-PC,as compared with ALA,PC and ALA+PC.The PO/W of ALA-PC was 7.8 times as that of ALA,while in vitro apparent permeability coefficient of ALA-PC increased significantly.More PpIX was induced by ALA-PC in normal mice skin,which existed in the deeper area.CONCLUSION ALA-PC was confirmed to be a new substance.The transdermal ability of ALA was improved after being complexed with PC.The results suggested that ALA-PC would be a promising transdermal delivery drug for photodynamic therapy.
2007, Vol. 42 