ZHENG Yi- nan1, LIU Ke-yue2��JIA Gui-yan3��LI Hui- ping1��HAN Li -kun4��Kimura Yoshiyuki5
1.College of Chinese Medicinal Material��Jilin Agricultural University��Changchun��130118��China��2. Jiujiang College��Jiujiang��332005��China��3. Faculty of Bromatology��Heilongjiang August First Land Recla University��Daqing 163319��China�� 4. Faculty of Environmental and Symbiotic Sciences��Prefectural University of Kumamoto��Kumamoto 862-8502��Japan�� 5. Division of Biochemical Pharmacology��Department of Basic Medical Research��Graduate School of Medicine��Ehime University��Shitsukawa��Toon City��Ehime 791-0295��Japan
Abstract��
OBJECTIVE To examine the inhibitory effect of the hot-water extract of coffee seeds on the postprandial blood glucose concentration in rats.METHODS The inhibitory effects of the hot-water extract of coffee seeds on the postprandial blood glucose concentration in Kud:Wistar rats were investigated by oral saccharinity tolerance test(OST) in vivo, and the suppression on ��-amylase and ��-glucosidase activity in vitro was evaluated.RESULTS The hot-water extract of coffee seeds strongly inhibited the activities of ��-amylase and ��-glucosidase,and reduced the postprandial blood glucose concentration.Chlorogenic acid,as well as acarbose,strongly inhibited the activity of ��-glucosidase,and reduced the postprandial blood glucose concentration.But caffeine,which was a major component of coffee seeds,had no such effect.CONCLUSION The inhibitory effect of the hot-water extract of coffee seeds on postprandial hyperglycemia may be due in part to the inhibition of ��-glucosidase by the chlorogenic acid,which is a major component of coffee seeds.
.Effect of Hot-Water Extract of Coffee Seeds on Postprandial Blood Glucose Concentration in Rats [J] Chinese Pharmaceutical Journal, 2007,V42(01): 32-35
2007, Vol. 42 