藁本内酯的研究进展

汪程远;杜俊蓉;钱忠明

中国药学杂志 ›› 2006, Vol. 41 ›› Issue (12) : 889-891.

中国药学杂志 ›› 2006, Vol. 41 ›› Issue (12) : 889-891.
综述

藁本内酯的研究进展

  • 汪程远,;杜俊蓉;钱忠明,
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摘要

目的综述了近40多年来国内外有关藁本内酯的研究进展。方法分析和归纳了有关藁本内酯的理化性质、药理作用、植物来源、提取分离、稳定性研究、化学合成等文献报道和相关专利的情况。结果与结论藁本内酯有较好的药理作用,极具开发价值,其在纯化分离、化学合成及制剂等方面研究较少且不够深入。

关键词

藁本内酯 / 理化性质 / 药理 / 提取分离

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汪程远;杜俊蓉;钱忠明 . 藁本内酯的研究进展[J]. 中国药学杂志, 2006, 41(12): 889-891

参考文献

[1] KOBAYASHI M, FUJITA M, MITSUHASHI H. Studies on the constituents of Umbelliferae plants.XV.Constituents of cnidium officinale:occurrence of pregnenolone, coniferylferulate and hydroxyphthalides[J] .Chem Pharm Bull,1987,35(4):1427-1433. [2] GIJBELS M, SCHEFFER J, BAERHEIM S A. Analysis of phthalides from Umbelliferae by combined liquid-solid and gas-liquid chromatography[J] .Chromatographia,1981,14(8):452-454. [3] MITSUHASHI H, NAGAI U, MURAMATSU T,et al. Constituents of Umbelliferae plants. II. Isolation of the active principles of ligusticum root[J] .Chem Pharm Bull,1960,8:243-245. [4] LI G S, MA C J, LIU Z F, et al. Extraction of essential oil from Angelica sinensis by supercritical-CO2 fluid in comparison with that by steam distillation [J] .Chin Tradit Herbal Drugs(中草药), 2001,32(7):581-584. [5] ZHANG X Z, XIAO H B, XU Q,et al. Characterization of phthalides in ligusticum chuanxiong by liquid chromatographic-atmospheric pressure chemical ionization-mass spectrometry[J] .J Chromatogr Sci,2003,41(8):428-433. [6] LI S B, ZHANG Z W, FANG X P,et al. The synthesis method of ligustilide. China,92111278.5[P] . 1994-10-21. [7] LIU J, WEI Y P,WANG J F. The extract process and application of Z-ligustilide. China, 03123994.3[P] .2004-09-25. [8] SHI L F, ZHENG X M. Comparison of influence of essential oil from Ligusticum Chuanxiong Hoert. On microcirculation in rabit conjunctive bulblar before and after decomposition of ligustilide[J] .Chin J Pharmacol Toxicol(中国药理学与毒理学杂志),1995,9(2):157-158. [9] YANG P Y, ZHANG W D, SU J. The treatment for atherosclerosis of ligustilide. China, 200310108859.6[P] .2004-08-12. [10] ZHAO X X. Ligustilide extracted from Dang Gui composition for treatment and prevention of gynecological disease. U.S. Pat. Appl. Publ.2002-87073[P] , 2003. [11] BOHRMANN H, STAHL E, MITSUHASHI H.Constituents of umbelliferous plants. XIII. Chromatographic studies on the constituents of Cnidium officinale[J] .Chem Pharm Bull,1967,15(10):1606-1608. [12] TAKANA I, YASUDA I, TAKAHASHI N,et al. Analysis of essential oils in various species of Angelica root by capillary gas chromatography[J] .Tokyo-Toritsu Eisei Kenkyusho Kenkyu Nenpo,1990,(41):62-69. [13] ZSCHOCKE S, LIU J H, STUPPNER H,et al. Comparative study of roots of Angelica sinensis and related umbelliferous drugs by thin layer chromatography, high-performance liquid chromatography, and liquid chromatography-mass spectrometry[J] .Phytochem Anal,1998,9(6):283-290. [14] LUO Y M. Research progress of ligusticum chaxiong[J] .J Jiangxi Univ Coll Tradit Chin Med(江西中医学院学报),1998,10(2):87-89. [15] ZHAO K J, DONG T, TU P,et al. Molecular genetic and chemical assessment of Radix angelica (Danggui) in China[J] .J Agric Food Chem,2003,51(9):2576-2583. [16] WANG C Y. Component study of Chuanxiong and medicinal materials in a prescription.Sichuan University Master Thesis[D] .2003. [17] LI G S, MA C J, LI X Y. Studies on the stability ligustilide and the analysis of its isomerized products by GC-MS[J] .Chin Tradit Herbal Drugs(中草药), 2000,31(6):405-407. [18] LI G S, LIU Y. Influence of steam distillation on the isomerization of the essential oils of Angelica Sinensis(Oliv.) diels[J] .Chin Tradit Patent Med(中成药),2001,23(11):784-786. [19] HU C Q, DING X L. Extraction, separation and identification of ligustilide in Dang Gui[J] .J Wuxi Univ Light Industry(无锡轻工大学学报),2003,22(9):69-71. [20] LUO Y M, PAN J G, DING K P. Anticonvulsive constituents in the essential oil of Chaxiong[J] .Chin Tradit Herbal Drugs(中草药),1996,27(8):456-567. [21] JIANG B, XU X F, WEI Q H. Isolation and identification of sedative constituents in the essential oil of Sinodiesisa Yunnanennsis[J] .Chin J Ethnomed Ethnopharm(中国民间民族医药杂志),1998,33(4):34-36. [22] LIN L Z,HE X G,LIAN L Z,et al.Liquid chromatographic-electrospray mass spectrometric study of the phthalides of Angelica sinensis and chemical changes of Z-ligustilide[J] .J Chromatography A,1998,810(1+2):71. [23] KANAMORI H,SAKAMOTO I. Evaluation of Angelicae radix. I. Purification method and stability of ligustilide[J] .Hiroshima-ken Eisei Kenkyusho Kenkyu Hokoku ,1992:3923-3926. [24] BOHRMANN H,STAHL E,MITSUHASHI H.Constituents of umbelliferous plants. XIII. Chromatographic studies on the constituents of Cnidium officinale[J] .Chem Pharm Bull,1967,15(10):1606. [25] ZHOU C X, LI X H. The comparison of stability and solvent effect for ligustilide[J] .Acta Pharm Sin(药学学报),2001,36(10):793. [26] LI H, WANG Y T. Influencing factor of the stability of ligustilide and means of stabilization[J] .J Jiangxi Coll TCM(江西中医学院学报),2003,15(1):56-57. [27] LI S B, ZHANG S M, LI S L. The synthesis research of ligustilide and (±)—butylidenephthalide[J] .Chem J Chin Univ(高等学校化学学报),1995,16(9):1420-1422. [28] BECK J J, STERMITZ F R. Addition of methyl thioglycolate and benzylamine to (Z)-ligustilide, a bioactive unsaturated lactone constituent of several herbal medicines. An improved synthesis of (Z)-ligustilide[J] .J Nat Prod,1995,58(7):1047-1055.

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