代谢组学用于外源物安全性评价研究进展

宋琳;吴晓建;刘昌孝;元英进

中国药学杂志 ›› 2006, Vol. 41 ›› Issue (12) : 881-885.

中国药学杂志 ›› 2006, Vol. 41 ›› Issue (12) : 881-885.
综述

代谢组学用于外源物安全性评价研究进展

  • 宋琳;吴晓建;刘昌孝,;元英进
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摘要

目的介绍代谢组学在安全性评价中的研究进展。方法总结代谢组学特点及主要技术,并介绍其在环境、食品和药物等外源物安全性评价方面的应用。结果代谢组学在安全性评价应用过程中不但正确预测了样本类别,同时成功的识别了可能的生物标志物。结论随着高分辨、高通量现代分析技术的进一步发展和生物信息学方法的不断改进,代谢组学必然带来了一场安全性评价的革命,同时也为中药的安全性评价提供了新的科学理论和方法学指导。

关键词

代谢组学 / 安全性评价 / 环境 / 食品 / 药物

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导出引用
宋琳;吴晓建;刘昌孝;元英进. 代谢组学用于外源物安全性评价研究进展[J]. 中国药学杂志, 2006, 41(12): 881-885

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天津市自然科学基金重点资助项目(05YFJZJC01103)

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