[1] COLLINS F S, GREEN E S, GUTTMACHER A E, et al. A vision for the future of genomics research[J] . Nature, 2003, 422: 835-847.
[2] JOHN R. Metabolomics——an important emerging science.Business briefing:pharmatech[J] . Drug Discov Today, 2004, 1:51-54.
[3] OLIVER S G, WINSON M K, KELL D B, et al. Systermatic functional analysis of the yeast genome[J] . Trends Biotechnol, 1998, 16:373-379.
[4] NICHOLSON J K, CONNELLY J, LINDON J C, et al. Metabonomics: A platform for studying drug toxicity and gene function[J] . Nat Rev Drug Discov, 2002, 1:153-159.
[5] THOMAS G H. Metabolomics breaks the silence[J] . Trends Microbiol, 2001, 9(4):158-159.
[6] WAGNER P. Analytical techniques Innovation, integration, information[J] . Curr Opin Biotechnol, 2003, 7:592-597.
[7] SCHMIDT C. Metabolomics takes its place as latest Up-and-coming “Omic” science[J] . J Natl Cancer Inst, 2004, 96:732-734.
[8] NICHOLSON J K, WILSON I D. Understanding `global' systems biology: metabonomics and the continuum of metabolism[J] . Nat Rev Drug Discov, 2003, 2:668-676.
[9] WECKWERTH W, FIEHN O. Can we discover novel pathways using metabolomic analysis?[J] .Curr Opin Biotechnol, 2002, 13:156-161.
[10] HOLMES E, ANTTI H. Chemometric contributions to the evolution of metabonomics: mathematical solutions to characterizing and interpreting complex biological NMR spectra[J] . Analyst, 2002, 127:1549-1557.
[11] LI J, WU X J, LIU C X, et al. Research and application of new method for data processing in metabonomics studies[J] . Acta Pharm Sin(药学学报),2006,41(1):47-53.
[12] HUBERT M, ENGELEN S. Robust PCA and classification in biosciences[J] . Bioinformatics, 2004, 20 (11):1728-1736.
[13] SCHOLZ M, GATZEK S, STERLING A, et al. Metabolite fingerprinting: detecting biological features by independent component analysis[J] . Bioinformatics, 2004, 20 (15):2447-2455.
[14] JANSEN J J, HOEFSLOOT H, BOELENS H, et al. Analysis of longitudinal metabolomics data[J] . Bioinformatics, 2004, 20 (15):2438-2461.
[15] ERIKSSON L, ANTTI H, GOTTFRIES J. Using chemometrics for navigating in the large data sets of genomics, proteomics and metabonomics (gpm)[J] . Anal Bioanal Chem, 2004, 380:419-429.
[16] WU X J, LI J, YUAN Y J. Progress and perspective in application of bioinformatics to metabonomics and metabolomics[J] . J Chem Ind Eng(化工学报), 2005,56:1819-1825.
[17] ANETOR J I, ADENIYI A A, OLALEYE S B. Molecular epidemiology: A better approach for the early detection of pathophysiologic response to environmental toxicants and disease[J] .African J Biomedical Res, 2003, 6:146-147.
[18] NOONAN C W,SARASUA S M,CAMPAGNA D,Effect of exposure to low levels of environmental cadmium on renal biomarkers[J] . Environ Health Perspect, 2002, 110:151-155.
[19] MUELLER M, KERSTEN S. Nutrigenomics: goals and strategies[J] . Nat Rev Genet, 2003,4:315-323.
[20] MATHERS J C. What can we expect to learn from genomics?[J] . Proc Nutr Soc, 2004,63:1-4.
[21] GERMAN J B, ROBERTS M A, WATKINSZ S M. Genomics and metabolomics as markers for the interaction of diet and health:lessons from lipids[J] . J Nutr, 2003, 133:2078-2083.
[22] AARDEMA M J, MACGREGOR J T. Toxicology and genetic toxicology in the new era of “toxicogenomics”: impact of “-omics” technologies[J] . Mutat Res Fund Mol Mech Mutagen, 2002, 499:13-25.
[23] NICHOLSON J K, WILSON I D. High resolution proton magnetic resonance spectroscopy of biological fluids[J] . Prog NMR Spectrosc, 1989, 21:444-501.
[24] GRIFFIN J L, WALKER L A, SHORE R F, et al. Metabolic profiling of chronic cadmium exposure in the rat[J] . Chem Res Toxicol, 2001,14:1428-1434.
[25] GRIFFIN J L, WALKER L, SHORE R F,et al. High-resolution magic angle spinning 1H-NMR spectroscopy studies on the renal biochemistry in the bank vole (Clethrionomys glareolus) and the effects of arsenic (As3+) toxicity[J] . Xenobiotica, 2001, 31(6):377-385.
[26] BUNDY J G, LENZ E M, BAILEY N J. Metabonomic investigation into the toxicity of 4-fluoroaniline, 3,5-difluoroaniline and 2-fluoro-4-methylaniline to the earthworm Eisenia veneta(Rosa): identification of novel endogenous biomarkers[J] . Environ Toxicol Chem, 2002, 21:1966-1972.
[27] LAFAYE A, JUNOT C, GALL B R, et al. Metabolite profiling in rat urine by liquid chromatography/ electrospray ion trap mass spectrometry. Application to the study of heavy metal toxicity Rapid Commun[J] . Mass Spectrom, 2003, 17:2541-2549.
[28] WATKINS S M, REIFSNYDER P R, PAN H J, et al. Lipid metabolome-wide effects of the peroxisome proliferator-activated receptor gamma agonist rosiglitazone[J] . J Lipid Res, 2002,43(11):1809-1817.
[29] HAN X, GROSS R W. Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics[J] . J Lipid Res, 2003, 44: 1071-1079.
[30] SU X, HAN X, YANG J, et al. Sequential ordered fatty acid a oxidation and D9 desaturation are major determinants of lipid storage and utilization in differentiating adipocytes[J] . Biochem, 2004, 43:5033-5044.
[31] LAMERS R J, GROOT J D, FABER F G. Identification of disease- and nutrient-related metabolic fingerprints in osteoarthritic guinea pigs[J] .J Nutr,2003,133:1776-1780.
[32] CATCHPOLE G S, BECKMANN M, ENOT D P, et al. Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops[J] .Proc Natl Acad Sci USA, 2005, 102:14458-14462.
[33] TEAGUE C, HOLMES E, MAIBAUM E, et al. Ethyl glucoside in human urine following dietary exposure: detection by 1H-NMR spectroscopy as a result of metabonomic screening in humans[J] . Analyst,2004, 129:259-265.
[34] SOLANKY K S, BAILEY N J, BECKWITH-HALL B M, et al. Application of biofluid 1H nuclear magnetic resonance-based metabonomic techniques for the analysis of the biochemical effects of dietary isoflavones on human plasma profile[J] . Anal Biochem, 2003, 323:197-204.
[35] HOLMES E, NICHOLSON J K, NICHOLLS A W, et al. The identification of novel biomarkers of renal toxicity using automatic data reduction techniques and PCA of proton NMR spectra of urine[J] . Chemom Intell Lab Syst, 1998, 44:245-255.
[36] HOLMES E, NICHOLSON J K, TRANTER G. Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks[J] . Chem Res Toxicol, 2001,14:182-192.
[37] COEN M, LENZ E M, NICHOLSON J K, et al. An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy[J] . Chem Res Toxicol, 2003, 16:295-303.
[38] COEN M, RUEPP S U, LINDON J C, et al. Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse[J] . J Pharm Biomed Anal, 2004, 35(1):93-105.
[39] LINDON J C, NICHOLSON J K, HOLMES E, et al. Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project[J] . Toxicol Appl Pharmacol, 2003, 187:137-146.
[40] KEUN H C, EBBELS T M D, ANTTI H, et al. Analytical reproducibility in 1H-NMR-based metabonomic urinalysis[J] . Chem Res Toxicol, 2002,15:1380-1386.
[41] PLUMB R, GRANGER J, STUMPF C, et al. Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LCTOFMS):detection of strain, diurnal and gender differences[J] . Analyst,2003,128:819-826.
[42] BJORKMAN H I, EDLUND P O, KVALHEIM O M, et al. Screening of biomarkers in rat urine using LC/electrospray ionization-MS and two way data analysis[J] .Anal Chem, 2003, 75:4784-4792.
[43] LIU C X, LI C, LIN D H, et al. Significance of metabonomics in drug discovery and development[J] .Asian J Drug Metab Pharmacokinet, 2004, 4(2):87-96.