1.School of Pharmacy�� Anhui Medical University�� Hefei 230032��China��2.Department of Pharmacy��the Hospital of the Seventeenth Metallurgical Construction Company��Maanshan 243000��China
Abstract��
OBJECTIVE To observe the pharmacokinetic interaction between captopril and low-dosage aspirin in dog.METHODS The main pharmacokinetic parameters of captopril(30 mg��kg-1)��aspirin( 1.5 mg��kg-1)and their combination were comparatively investigated in an open randomized crossover study. Drug concentration in plasma was assayed by RP-HPLC method. Concentration-time curves were simulated by 3P87 program.RESULTS Compared with the group treated with captopril alone, Ke increased significantly and t1/2 decreased significantly in the group with combined treatment. There was no significant difference in cmax,tmax and AUC. No statistical significant difference was found in the pharmacokinetic parameters between the group treated with aspirin alone and in the group with combined treatment. CONCLUSIONS The results suggested that aspirin stimulated the activity of drug-metabolizing enzymes and produced pharmacokinetic interaction with captopril, which resulted in the differences in Ke, t1/2Ke and AUC of captopril. However,there was no effect on aspirin itself.
2005, Vol. 39 
