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�й�ҩѧ��־ 2005, Vol. 39 Issue (07) :499-501    DOI:
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1.�й�ҩ�ƴ�ѧ��ҩѧ�о��� ���� �Ͼ� 210038;2.�Ϻ���ҩ��׼���о����� �Ϻ� 201203;3.�Ϻ���������ҩ��Ƭ�� �Ϻ� 200434
ZHANG Mian1��XU De-ran1�� REN Qiang1�� ZHANG Zi-jia1�� WU Tao2�� LIU Lei3
1.Department of Pharmacognosy�� China Pharmaceutical University�� Nanjing 210038�� China�� 2.Shanghai Research Center for Standardization of TCM�� Shanghai 201203�� China�� 3.Shanghai Leiyunshang Processed Drug Plant of TCM�� Shanghai 200434�� China

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ժҪ Ŀ�IJ��ø�ЧҺ��ɫ�׷��Ƚϴ����ҩ������ǰ�������໯���ﺬ���ı仯�������Դ���غʹ�Ʒ�Ϊ����Ʒ,����Merck C18ɫ����(4.6mm��250mm,5��m),�״�-ˮ-����(78.7:20.9:0.4)Ϊ������,��Ⲩ��254nm,��귨�ⶨ���������ص����Է�ΧΪ0��44.7��g��mL-1,r=1.0000,ƽ��������Ϊ98.5%,RSD=1.20%;��Ʒӵ����Է�ΧΪ0��42.7��g��mL-1,r=1.0000,ƽ��������Ϊ96.7%,RSD=1.48%��˵���÷������ڴ��ҩ���д���غʹ�ƷӺ����IJⶨ�Ǻ�����еġ����۴����ҩ������ǰ��,����غʹ�Ʒӵĺ��������˱仯���������Ʒ(8/11)��Ƭ�еĺ�������ҩ��,��������Ʒ(3/11)�����෴��
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Abstract�� OBJECTIVE To compare the contents of anthraquinones in the crude drugs with that in the corresponding processed rhubarb by HPLC method.METHODS With emodin and chrysophanol as the reference, the separation was conducted on the column of Merck C18(4.6 mm��250 nim,5 ��m), using the mixture of methanol-water-H3PO4(78.7:20.9:0.4) as the mobile phase. The detection wavelength was at 254 nm. RESULTS The linear range for emodin was over 0��44.7��g��mL-1 (r =1.000 0) and the average recovery was 98.5% (RSD = 1.20% ) .The linear range for chrysophanol was over 0��42.7 ��g��mL-1(r =1.000 0) and the average recovery was 96.7% (RSD =1.48% ). The results showed that the developed HPLC method was reliable for the determination of emidin and crysophanol contained in the rhubarb. CONCLUSION The contents of emodin and chrysophanol in the crude was drug different from that in the corresponding processed drug.For most samples (8/11), the total content in the processed drug were higher than that in the corresponding crude drug, but a few of samples (3/11) were reversed.
Keywords�� rhubarb,   crude drug,   processed drug,   emodin,   chrysophanol      
�ո�����: 2004-01-16;
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.�����ҩ������ǰ�������໯���ﺬ���ı仯[J]  �й�ҩѧ��־, 2005,V39(07): 499-501
.Comparison with the contents of anthraquinones between the crude drugs and the processed drugs of rhubarb[J]  Chinese Pharmaceutical Journal, 2005,V39(07): 499-501
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