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�й�ҩѧ��־ 2005, Vol. 39 Issue (07) :495-497    DOI:
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1.��ž���306ҽԺҩ���� ���� 100101;2.�������������ɴ�ѧҩѧԺ ���� NC 27599;3.�ڶ���ҽ��ѧҩѧԺ �Ϻ� 200433
WU Jiu-hong1�� SHI Ning1�� PAN Min-xiang1�� WANG Xi-hong2�� YI Yang-hua3
1.Department of Pharmacy��306 Hospital of PLA��Beijing 100101�� China��2. Natrual Products Laboratory�� School of Pharmacy�� University of North Carolina��Chapel Hill��NC 27599�� USA��3. School of Pharmacy��Second Military Medical University��Shanghai 200433�� China

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ժҪ Ŀ�Ĵӷ���֦��ëҶ��ӥצ����,��ȡ����õ����п����̲������Ե����ʡ��������û���׷�ٵķ���,���ܼ���ȡ�Ͷ���ɫ�׷�������õ����Ի�����,�����׷���(UV,IR,MS,1H-NMR,13C-NMR��X-ray��)ȷ�������ǵĽṹ������õ����־��п����̲������ԵĻ�����:2-������-3-�׻�-4,6-���ǻ�-5-(3'-�ǻ�)�����������ȩ,Ϊһ�ֽṹ����IJ��ͪ�໯����,����ΪëҶ��ӥצ��D(desmosdumotinD)����һ�ֻ��Ի�����Ϊӥצ��(lawinal)������ëҶ��ӥצ��DΪ�״δ�ëҶ��ӥצ�з���,�״α������ͪ�໯������п�HIV���ԡ�
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Abstract�� OBJECTIVE To isolate anti-HIV compounds from the root of Desmos dumosus. METHODS Bioactivity-directed isolation was used to find compounds and their structures were elucidated by spectra (UV,IR,MS,1H-NMR,13C-NMR and X-ray et al).RESULTS Two compounds were obtained. 2-Methoxy-3-methyl-4,6-dihydroxy-5-(3'-hydroxy) cinnamoylbenzaldehyde was a chalcone with novel structure, named as desmosdumotin D. Lawinal was also demonstrated its anti-HIV activity. CONCLUSION desmosdumotin D was isolated from this plant for the first time. Chalcone which processed anti-HIV activity was first reported.
Keywords�� desmosdumotin D,   lawinal,   anti-HIV activity,   Desmos Lour      
�ո�����: 2004-03-23;
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.ëҶ��ӥצ����ѧ�ɷּ��俹���̲������Ե��о�[J]  �й�ҩѧ��־, 2005,V39(07): 495-497
.Studies on the structure and activity of anti-HIV compounds in Desmos dumosus[J]  Chinese Pharmaceutical Journal, 2005,V39(07): 495-497
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