摘要
目的建立计算机辅助的成像分析平台,分别考察市售的空白丸芯和自制的GBE微丸的圆整度。方法采用计算机辅助的成像分析法。结果空白丸芯和GBE微丸的纵横比(AR)值分别为1.16±0.09,1.14±0.09(n=25),形状因子(eR)值分别为0.56±0.12,0.62±0.14(n=25)。结论该方法能够直观、简便地评价微丸的圆整度,所制备的GBE微丸圆整度较好。
Abstract
OBJECTIVE To establish a computer assistant image system for investigating the pellets sphericity. METHODS The computer assistant image analysis was applied. RESULTS The aspect ratios of the blank and GBE pellets were 1.16±0.09,1.14±0.09(n=25),and the shape factors (eR) were 0.56 ± 0.12,0.62 ±0.14(n=25).CONCLUSION The pellets sphericity can be evaluated directly and conveniently by the computer assistant image analysis. The sphericity of GBE pellets was desirable.
关键词
计算机辅助 /
成像分析 /
微丸 /
圆整度
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Key words
computer assistant /
image analysis /
pellet /
sphericity
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王俊;周寅;曹志娟;赖顺果;裴元英.
计算机辅助成像分析法在微丸圆整度评价中的应用[J]. 中国药学杂志, 2005, 40(07): 529-531
WNG Jun;ZHOU Yin;CO Zhi-jun;LI Shun-guo;PEI Yun-ying.
Evaluation of pellets sphericity using computer assistant image analysis [J]. Chinese Pharmaceutical Journal, 2005, 40(07): 529-531
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参考文献
[1］陆彬.药物新制剂与新技术 [M］.北京：人民卫生出版社，1998： 289.
[2］Podczeck F， Rahman SR， Newton JM. Evaluation of a standardised procedure to assess the shape of pellets using image analysis [J］.Int J Pharm，1999，192(2)：123.
[3］Paterakis PS， Korakianiti ES， Dallas PP，et al. Evaluation and simultaneous optimization of some pellets characteristics using a 3(3) factorial design and the desirability function[J］.Int J Pharm，2002， 248(1-2)：51.
[4］Podczeck F， Newton JM. A shape factor to characterize the quality of spheroids [J］.J Pharm Pharmacol，1994，46(2)：82.
[5］Vervaet C， Remon JP. Influence of impeller design， method of screen perforation and perforation geometry on the quality of pellets made by extrusion-shperonisation[J］.Int J Pharm，1996，133(1～2)：29.
[6］陈挺，陈庆华.盐酸苯丙醇胺微丸的制备工艺研究 [J］.中国医药工业杂志，1999，30(8)：345.
[7］Podczeck F， Newton JM. The evaluation of a three-dimensional shape factor for the quantitative assessment of the sphericity and surface roughness of pellets[J］.Int J Pharm，1995，124(2)：253.
[8］胡富强，袁弘，戴缨，等.载体对粉雾剂粉末流动性的影响[J］.中国药学杂志，2002，37(2)：115.
[9］Andersson M， Holmquist B， Lindquist J，et al. Analysis of film coating thickness and surface area of pharmeutical pellets using fluorescene microscopy and image analysis [J］.J Pharm Biomed Anal，2000， 22(2)：325.
[10］Larsen CC， Sonnergaard JM， Bertelsen P，et al. Validation of an image analysis method for estimating coating thickness on pellets [J］.Eur J Pharm Sci，2003，18(2)：191.
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脚注
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