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�й�ҩѧ��־ 2005, Vol. 39 Issue (02) :115-119    DOI:
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1.�Ϻ���ҽҩ��ѧ��ҩѧԺҩ�������� �Ϻ� 201203;2.����ҩ�ƴ�ѧҩ�������� ���� ���� 110016
ZHENG Hang-sheng1,BI Dian-zhou2
1. Department of Pharmaceutics, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; 2. Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016,China

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Abstract�� OBJECTIVE To improve the drug release reproducibility of elementary osmotic pump tablets and to investigate its drug release mechanism with a new method.METHODS The KCl osmotic pump tablets were prepared with a single punch press and pan coating techniques.The effective factors on the drug release, such as suspension agents in the tablet core,the direction and the diameter of drug release orifices,the rotation speed of dissolution testers, the thickness of coating film, PEG400 content in coating film and the hardness of tablet core, were investigated by dissolution tests.The drug release of the tablets with one orifice or two orifices was determined, respectively.RESULTS The direction of drug release orifices affected the release of tablets without suspension agent, but it had no effect on the tablets with suspension agent The rate of drug release increased with the decreasing of coating film thickness, or with the increasing of the PEG400 content in the coating film Other factors had little effects on the drug release. The drug release behaviors of the tablets with one orifice were almost identical to those of the tablets with two orifices.CONCLUSION It is essential to add suspension agents to tablet core in order to get good drug release reproducibility.The thickness of the coating film and its PEG400 content are two main factors controlling drug release rate.The dosage form mainly releases its drug with osmotic pressure mechanism.The new method to investigate the drug release mechanism is convenient and practicable.
Keywords�� osmotic pump tablets,   potassium chloride,   drug release rules,   drug release mechanism     
�ո�����: 2004-04-18;
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֣����, �ϵ���, ֣������ .�Ȼ�����͸���Ϳ���Ƭ����ҩ���ɼ����Ƶ��о�[J]  �й�ҩѧ��־, 2005,V39(02): 115-119
ZHENG Hang-sheng, BI Dian-zhou, ZHENG Hang-sheng etc .Study on drug release and its mechanism of potassium chloride osmotic pump tablets[J]  Chinese Pharmaceutical Journal, 2005,V39(02): 115-119
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