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�й�ҩѧ��־ 2004, Vol. 40 Issue (05) :366-368    DOI:
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CHEN Qiong,DONG Xue-chuan,SHI Shao-jun,GU Shi-fen,CHEN Hui
Department of Pharmacology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

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ժҪ Ŀ�� ����BeagleȮ������������ּ�(DS)��������(Dau)��ҩ��ѧ-ҩЧѧ(PK-PD)���ģ�͡����� ͨ���ⶨ��ҩ��BeagleȮ���ڵ�ѪҩŨ�Ȳ��Ը�ҩ���Q-Tc�����ӳ�����ΪЧӦָ��,����Sheiner�������PK-PD���ģ�ͽ���PK-PD����о������ ҩ��ЧӦ��ЧӦ��Ũ�ȳ����õ������,����Sigmoid-Emaxģ��,��ͨ������ó���Ӧ��PK-PDģ�Ͳ��������� ��������BeagleȮ���ڳɹ��ؽ�����DS��Dau��PK-PD���ģ��,������ҩ��ЧӦE,ѪҩŨ��Cp��ʱ��t֮��Ĺ�ϵ,�ʿɽ�Ϊ�ɹ���Ԥ��DS��Dau��ѪҩŨ�ȼ���ЧӦ��
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Abstract�� OBJECTIVE To establish the pharmacokinetic-pharmacodynamic (PK-PD) characteristics of daurisoline (DS) and dauricine (Dau) in Beagle dogs. METHODS The plasma concentrations of DS and Dau were determined and the prolongation percentage of Q-Tc interval was observed as the effect index. The Sigmoid-Emax model was used to analyze the relationship among the plasma concentrations, time and effects of DS and Dau. RESULTS The relationship between effect and plasma concentration met the Sigmoid Emax model and the model parameter (Ke0 , Emax, EC50,��) were calculated. CONCLUSION The PK-PD model of DS and Dau and the relationship among the effect, plasma concentration and time are established successfully.
Keywords�� daurisoline,   dauricine,   pharmacokinetic-pharmacodynamic linked model      
�ո�����: 2003-01-20;
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����, ��ѩ��, ʦ�پ��� .��������ּ��������Ȯ����ҩ��ѧ-ҩЧѧ����о�[J]  �й�ҩѧ��־, 2004,V40(05): 366-368
CHEN Qiong, DONG Xue-chuan, SHI Shao-jun etc .Study on the pharmacokinetic-pharmacodynamic characteristics of daurisoline and dauricine in Beagle dogs [J]  Chinese Pharmaceutical Journal, 2004,V40(05): 366-368
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