1.Department of Clinical Pharmacy,The Second Affiliated Hospital,College of Medicinal Sciences,Zhejiang University,Hangzhou 310009,China;2.Department of Biomedical Engineering,Zhejiang University,Hangzhou,310027,China
Abstract��
OBJECTIVE To investigate the immune enhancing effects in vitro of Rg3 on peripheral lymphocytes of cancer patients treated with radiotherapy. METHODS The peripheral lymphocytes were separated and purified from the cancer patients 24 h after radiotherapy. The cells were cultured with different concentrations of Rg3 for 48 h or 72 h, and then the lymphocytes proliferation, cytokines and membrane marker were assessed with flow cytometer. RESULTS Rg3 enhanced lymphocytes proliferation induced by ConA, promoted the expression of HLA-DR, HLA-ABC, CD3 and CD56+16, and increased the ratio of CD4+/CD8+. and Th1/Th2. CONCLUSION Rg3 can improve the immune function of peripheral lymphocytes in cancer patients treated with radiotherapy, including specific and nonspecific immune functions.
ZHANG ZHong-miao,
JIANG Bo,
ZHENG Xiao-xiang etc
.Immune enhancing effects of Rg3 on peripheral lymphocytes in vitro in cancer patients treated with radiotherapy [J] Chinese Pharmaceutical Journal, 2004,V40(04): 261-263
2004, Vol. 40 
