摘要
目的:介绍90年代发展起来的新合成生长激素释放肽(GHRPs)及非肽促泌素的研究应用进展?方法:根据1990~1997年有关文献,综述这类新药的生物活性、作用机制和药效学的研究发展及其在生命科学领域中的应用?结果:生长激素释放肽-6,生长激素释放肽-2,生长激素释放肽-1,海沙瑞林以及非肽促泌素MK-0677和L-692,429等均具有显著的释放生长激素的作用和疗效?结论:合成的生物活性肽以生长激素释放肽-6和海沙瑞林具有较广阔的应用前景?
关键词
生长激素释放肽 /
合成的生物活性肽 /
非肽促泌素
{{custom_keyword}} /
陈执中.
生长激素释放肽及非肽促泌素的研究应用进展[J]. 中国药学杂志, 1999, 34(08): 505-508
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
1 Majer Z,Zawdu M,Hollosi M,et al.Solid phase sysnthesis of a GHRP analog containing C-temainal thioamide group.Biochem Biophys Res Commum,1988,150(3):1017.
2 Prusik Z,Kasicka V,Mudra P,et al.Correlation of capillary zone electrophoresis with continuous freeflow zone electrophoresis:a plication to the analysis and purification of synthetic growth hor-mone releasing peptide.Electrophoresis,1990,11(11):932.
3 Bowers C Y.GH releasing peptide——structure and kinetics.J Pediatr Endocrinol,1993,6(1):21.
4 Korbonits M,Grossman AB.Growth hormone-relasing Deptides(GHRP)and their analogues.Orv Hetil,1996,137(45):2503.
Deghenghi R.The development impervious peptides as growch hormone secretagogues.Acta Paediatr Scand(Suppl),1997,423:85.
6 Walker RF,Codd EE,Barone FC,et al.Oral activity of the growth hormone releasing:peptide-6 in rats,dogs and monkeys.Life Sci,1990,47(1):29..
7 Nelson AH,Walker RF,Codd EE,et al.Intranasal activitv of the growth hormone releasing peptide GHRP-2 in conscious dogs.Life Sci,1991,48(23):2283.
8 Hayashi S,Okimura Y,Yagi H,et al.Intranasal hormone and insulin-like growth factor-I levels in normal men.Endocrinol Jpn,1991,38(1):15.
9 Bercu BB,Walker RF.Growth hormone secreragogues in children with altered growth.Acta Peadiatr Scand(Suppl),1997,423:102.
10 Laron Z,Eower CY,Hirsch D et al.Growth hormone-releasing ac-tivity of growth hormone-rdeasing peptide-1(a synthetic heprapep-tide)in children and adolescents.Acta Endocrinol(Copenh),1993,129(5):424.
11 Deghenghi r,Gananzi MM,Torsello A,et al.GH releasing activity of Hexarelin,a new growth hormone releasing peptide,in infant and adult rats.Life Sci,1994,54(18):1321.
12 C-ells SG,Locatelli V,Poratelli M.Hexarelin.A potent GHRP ana-logue:interaction with GHRH and clonidin in young and aged dogs.Peptides,1995,16(1).81.
13 Smith RG,Cheng K,Schoen WR.A nonpeptidyl growth secreta-gogue.Science,1993,260(5114):1640.
14 Cheng K,Chan WW,Butler B,et a1.A novd non-pepfidyl growth hormone secretagogue.Horm Res,1993,40(1~3):109.
15 Cheng K,Chan WW,Butler B,et al.Stimulation of growth hormone release from rat primary pituitary ceIl by L-692,429,a novel nonpeptidyl GH secretagogue.Endocrinology,1993,132(6):2729.
16 Blake AD,Smith RG.Desensitization studies nsing perifused rat pipuitary cells show that growth hormone-releasing hormone and GHRP-6 stimulate growth hormone release through distinct recep-tor sites.J Endocrinol,1991,129(1):11.
17 Akman MS,Girard M,O’Brien LF,et al.Mechanisms of action of a second generation growth hormone-releasirtg peptide GHRP-1 in rat anterior pituitary cells.Endocrinology,1993,132(3):1286.
18 Mckee KK,Palyha OC,Feighner SD,et al.Molecular analysis of rat.Pituitary and hypithatamic growth hormone secretagogue recep-tors.Mol Endocrinol,1997,11(4):415.
19 Ghigo E,Arvat E,Mucciol F,et al.Growth hormone-releasing peptides.Eur J Endocrinol,1997,136(5):445.
20 Roh SG,He ML,Matsunaga N et al.Mechanisms of action of growth hormone-releasing peptide-2 in bovine pituitary cells.J An-im Sci,1997,75(10):2744.
21 Bennett PA,Thomas GB,HowaM AD,et al.Hypothalamic growth hormone secretagogue-receptor(GHS-R)expression is regutated by growth hormone in rat.Endocrinology,1997,138(11):4552.
22 McDowell RS,Ellas KA,Stmley MS,et al.Growth hormone seere-tagogues:charactorization,efficacy,and minimal bioactive confor-mation.Proc Natl Acad Sci USA,1995,92:11165.
23 Kendall-Taybr P,Paxton A,Koppiker NP.Observation on the stimulation of growth hormone secretion in patients with growth hormone deficiency.Metabolism,1996,45(8 Suppl 1):127.
24 Villas-Bas Weffort RF,Ramos-Dias JC,Chipoch C,et al.Growth hormone (GH) response to GH-releasing pepide-6 in patients with insulin-dependent diabetes mellitus.Metabolism,1997,46(6):706.
25 Pimentel-Filho FR,Ramos-Dias JC,Ninno FB,et al.Growth hor-mone responses to GH-releasing peptide(GHRP-6)in hypothy-oidism.Clin Endocrinol(Oxf),1997,46(3):295.
26 Pihoker C,Badger TM,Reynolds GA,et.al.Treatment efiects of intranasal growth hormone releasing peptide-2 in children with short stature.J Endocrinol.1997,155(1):79.
27 Earon Z,Frenkel J,Deghenghi R.Intranasal administration of the CHRP hexarelin accelerates growth in short children.Clin En-docrinol(Oxf),1995,43(8):631.
28 Ghigo E,Arvat E,Gianotti L,et al.Short-term administration of intranasal or oral hexardin,a synthetic hexapeptide.Does not desen-Sitize the growth hormone responsiveness in human aging.Eur J Endocrinol,1996,135(4):407.
29 Chapman IM,Pescoritz OH,Murphy G,et al.Oral administration of growth hormone(GH)releasing peptide-mimetic MK-677 stimulates GH-insulin-like growth factor-I axis in selected GH-defi-cient adult.J Clin Endocrinol Metab,1997,82(10):3455.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}