Abstract��
OBJECTIVE: The bioavailability of famotidine sustainedrelease tablets was studied in 16 healthy volunteers. METHODS:BZThe famotidine plasma levels were determined by HPLC method,and the plasma leveltime data were proessed by 3P87 pharmacokinetics procedure. RESULTS: The results showed that the peak plasma level occurring at(7.12��0.40)h was (58.69��4.30)ng��ml-1,and its relative bioavailability was (117.0��8.9)% after a single dose oral administration;The peak pasma level was (70.72��4.61)ng��ml-1,the fluctuating degree (FD) was (121.6��11.4)%,and its relative bioavailability was (117.9��23.46)% at steady state after multiple dose oral administration. CONCLUSION: The effect of the sustainedrelease tablets is basically equivalent to that of the normal tablets on marketing.
Zeng Huanxiang,
Zeng Huanxiang
.Study on bioavailability of famotidine sustained-release tablets in healthy volunteers[J] Chinese Pharmaceutical Journal, 1999,V34(08): 545-549
1999, Vol. 34 
