OBJECTIVE: The bioavailability of famotidine sustainedrelease tablets was studied in 16 healthy volunteers. METHODS:BZThe famotidine plasma levels were determined by HPLC method,and the plasma leveltime data were proessed by 3P87 pharmacokinetics procedure. RESULTS: The results showed that the peak plasma level occurring at(7.12±0.40)h was (58.69±4.30)ng·ml-1,and its relative bioavailability was (117.0±8.9)% after a single dose oral administration;The peak pasma level was (70.72±4.61)ng·ml-1,the fluctuating degree (FD) was (121.6±11.4)%,and its relative bioavailability was (117.9±23.46)% at steady state after multiple dose oral administration. CONCLUSION: The effect of the sustainedrelease tablets is basically equivalent to that of the normal tablets on marketing.
Zeng Hunxing.
Study on bioavailability of famotidine sustained-release tablets in healthy volunteers[J]. Chinese Pharmaceutical Journal, 1999, 34(08): 545-549
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