Abstract��
OBJECTIVE: The bioavailability and pharmacokinetics of the domestic cefactor tablets was compared with those of cefaclor capsule made in USA. METHOD: A single oral dose of 500mg cefaclor was given according to cross over design in 10 healthy volunteers.Plasma levels of cefaclor were measured by high-performance liquid chromatography method,The concentration-time curve of cefaclor was fitted to one compartment model measured by 3P87 program. RESULTS: The pharmacokinetic parameters of domestic and imported cefaclor were cmax(9.87��1.07)mg��L-1and (10.44��0.89)mgd��L-1;tmax(0.45��0.04)h and (0.44��0.07)h;t1/2(0.84��0.07)h and (0.87��0.11)h;AUC(16.69��1.74)mg��h��L-1 and (18.02��1.42)mg��h��L-1,respectively.The relative bioavailability of domestic tablet was 92.62%. CONCLUSION: The results by two-one sided t-test showed that the two formulation of domestic and imported products were bioequivalent.
1999, Vol. 34 
