大豆磷脂胶丸稳定性的初步观察

何新霞;徐丽珊;杨玲

中国药学杂志 ›› 1999, Vol. 34 ›› Issue (08) : 538-540.

中国药学杂志 ›› 1999, Vol. 34 ›› Issue (08) : 538-540.
药剂

大豆磷脂胶丸稳定性的初步观察

  • 何新霞;徐丽珊;杨玲
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Preliminary observations on the stability of phospholipid capsules

  • He Xinxia
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摘要

目的:研究大豆磷脂胶丸的稳定性?方法:进行影响因素试验、加速试验、室温留样考察及低温留样考察,考察本品的外观、崩解时限、乙醇溶液的颜色、含量及降解产物等,并与0时的数据、图谱进行比较?结果:本品60℃放置胶丸变形、破碎、内容物色泽加深,第10天时有降解;40℃,RH75%放置1,2,3个月均有降解、内容物色泽加深,3个月时崩解时限延长?结论:本品对高温、高湿度均不稳定,其它考察条件稳定?

Abstract

OBJECTIVE: The stability of phospholipid capsules was preliminarily studied. METHOD: The appearance,disintegration time,color of alcohol solution,content and degradation products were observed and analyzed under the test of influencing factors,accelerating test,inspecting test at room temperature and low temperarure,respectively.And the results were compared with those at 0 hour. RESULTS: Under 60, the capsules became deformed and broken.The color of the content became dark.The degradation products appeared at the tenth day.Under 40 with RH 75%,degradation products appeared.The color of content became dark in the first month,the second month and the third month, respectively.disintegration time was prolonged in the third month. CONCLUSION: The phospholipid capsules were unstable at high temperature and high hAuthor umidity, but stable under other inspecting conditions.

关键词

大豆磷脂 / 胶丸 / 稳定性

Key words

phospholipid / capsules / stability test

引用本文

导出引用
何新霞;徐丽珊;杨玲. 大豆磷脂胶丸稳定性的初步观察[J]. 中国药学杂志, 1999, 34(08): 538-540
He Xinxi. Preliminary observations on the stability of phospholipid capsules[J]. Chinese Pharmaceutical Journal, 1999, 34(08): 538-540

参考文献

1 蒋兴仁.国外磷脂健康食品介绍.食品工业科技,1990,(4):12. 2 浙江省卫生厅编.浙江省药品标准1993年版.1993:301. 3 中国药典1995年版.二部:附录17. 4 Marinentti G V.Lipid Chromatographic Analysis Volume 3.2nd ed.New York:Marceldekker INC.1976:760.

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