Abstract��
OBJECTIVE: To optimize the synthesis of riboflavin and to reduce its production cost. METHODS: The reported synthetic route was simplified using the alcoholic solution of cheap D-ribose from the fermentation broth to react with 3,4-xylidine in hydrogenation. RESULTS: Final product riboflavin was got by only three steps with total yield of 40%. CONCLUSION: The tedious processing of D-ribose was discarded and the purified fermentation broth of D-ribose could be used directly in hydrogenation Thus, the synthesis of riboflavin was simplified and the production cost was reduced notably.
1999, Vol. 34 
