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�й�ҩѧ��־ 1999, Vol. 34 Issue (08) :562-564    DOI:
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Sun Wenjing
(Sun WJ)��Gao Runxiang(Gao RX)��Xie Hong(Xie H)��et a

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Abstract�� OBJECTIVE: To optimize the synthesis of riboflavin and to reduce its production cost. METHODS: The reported synthetic route was simplified using the alcoholic solution of cheap D-ribose from the fermentation broth to react with 3,4-xylidine in hydrogenation. RESULTS: Final product riboflavin was got by only three steps with total yield of 40%. CONCLUSION: The tedious processing of D-ribose was discarded and the purified fermentation broth of D-ribose could be used directly in hydrogenation Thus, the synthesis of riboflavin was simplified and the production cost was reduced notably.
Keywords�� riboflavin,   technical improvement     
�ո�����: 1998-11-30;
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.�˻��غϳ�·�ߵ��Ż�[J]  �й�ҩѧ��־, 1999,V34(08): 562-564
.Optimized synthesis of riboflavin[J]  Chinese Pharmaceutical Journal, 1999,V34(08): 562-564
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