目的:采用固体分散法制备了硝苯地平长效缓释片,并测定体外释放度?方法:比较了0.1mol·L^-1HCl,pH6.8磷酸缓冲液,体积分数为2.5%,5%和10%乙醇溶液对本品释放度的影响?用紫外分光光度法,在340nm波长处测定吸光度?结果:试验结果表明,介质pH的改变对释放度没有影响,本品在体积分数为5%乙醇溶液中的释放度较合适,24h累计释放度达93.1%,本品在体积分数为5%乙醇介质中以50r·min^-1速度释药与体内吸收速度有较好的相关性(r=0.9917)?

OBJECTIVE:Nifedipine long action sustained release tablet was prepared with solid dispersion,dissolution rate was determined.METHODS:Compared with release rate of the tablet in different dissolution medium,for example 0.1mol·L^-1HCl,pH6.8 PBS,2.5%,5% and 10% alcohol solution.RESULTS:The results showed that 5% alcohol was suitable among the five dissolution mediums,being less affected by pH value of the dissolution medium to release rate of nifedipine from the tablet.The relationships between in vitro dissolution and in vivo absorption indicated that there were good correlations.The correlation coefficients of precent dissolution vs absorption was 0.9917.