目的：寻求具有抗惊厥活性，容易进入脑内的非毒性的γ-氨基丁酸衍生物。方法：通过亚胺键将γ-氨基丁酸接到一个亲脂性载体上，设计并合成了16个γ-氨基丁酸衍生物，测试其抗惊厥活性。结果：有6个化合物具有抗惊厥活性。结论：通过亚胺键将一个亲脂性载体接到γ-氨基丁酸上制成的衍生物可能具有抗惊厥活性。
Abstract
OBJECTIVE:To study nontoxic derivatives of γ-aminobutyric acid which may easily enters the brain and have anticonvulsant activity.METHOD:16 derivatives of γ-aminobutyric acid with an imine link to a lipophilic carrier were prepared and tested for anticonvulsant activity. RESULTS:6 compounds showed anticonvulsant activity.CONCLUSION:It indicated that a derivative of γ-aminobutyric acid with an imine link to a lipophilic carrier may have useful anticonvulsant activity.
关键词
γ-氨基丁酸衍生物 /
合成 /
抗惊厥活性
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Key words
γ-aminobutyric acid derivatives /
synthesis /
anticonvalsant activity
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参考文献
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脚注
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