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�й�ҩѧ��־ 1998, Vol. 33 Issue (11) :680-683    DOI:
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Yang Yongjian
(Yang YJ

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Abstract�� OBJECTIVE:To introduce a method for determination of size distribution of powders for inhalation by multistage liquid impinger,and study the effects of flow rate and structure of turbuhaler on the size distribution of budesonide powders for inhalation.METHOD:The contents of budesonide in different size range were determined by multistage liquid impinger and HPLC.RESULTS:The size distribution of budesonide powders for inhalation was affected by flow rate and structure of turbuhaler.The amount of the drug inhaled increased proportionally to the flow rate in the range of 30 L��min-1��60 L��min-1.CONCLUSION:Multistage liquid impinger method is proved to be effective and accurate for quality control of powders for inhalation.
Keywords�� budesonide,   powders for inhalation,   size distribution of powders     
�ո�����: 1998-02-13;
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.�����ε·������΢���ֲ��о�[J]  �й�ҩѧ��־, 1998,V33(11): 680-683
.Study on the size distribution of budesonide powders for inhalation [J]  Chinese Pharmaceutical Journal, 1998,V33(11): 680-683
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