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�й�ҩѧ��־ 1998, Vol. 33 Issue (04) :229-232    DOI:
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�ٴ�ҩ��ѧ��ҩ���廯ϵͳ�����Ƽ�Ӧ��
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Xia Dongya
(Xia DY)��Shen Xiaohun (Shen XH)��Liu Baoqing (Liu BQ)��et a

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ժҪ Ŀ�ģ�Ϊ�����ٴ��������ѪҩŨ�����ݹ��㲡�˵ĸ���ҩ��ѧ�������Ż���ҩ��������ơ��������ٴ�ҩ��ѧ��ҩ���廯ϵͳ��CPKDP���򣩡�����������Ⱥ��ҩ��ѧԭ��Bayes��ʽ��CPKDP������FOXPRO 2.6��BORLAND C++ 3.1��������ϣ������ϵͳUCDOS 5.0ƽ̨�����С������CPKDP���������ھ��в�ͬҩ��ѧ�����Ķ���ҩ������ڲ�ͬ��ҩ;���ĵ�������������ҩ����Ⱥ��ҩ��ѧ�����Ļ����ϣ���ϲ��˸�����������1��2ѪҩŨ����Ϊ������������Ϲ������ҩ��ѧ�������Ż���ҩ���������ۣ�������Ӧ�ã�CPKDP������Ӧ��Bayes��������չ�ٴ����廯��ҩ�����dz�ʵ�õĹ��ߡ�
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Abstract�� OBJECTIVE: To design and develop a clinical pharmacokinetics and individual drug dosage regimens system (CPKDP program) for estimating individual pharmacokinetic parameters and optimizing individualizing dosage regimens using routine clinical data of plasma levels. METHODS: According to the principle of population pharmacokinetics and Bayes' formula, CPKDP program was written with FOXPRO 2.6 and BORLAND C++ 3.1, and was run on 486 microcomputer with UCDOS 5.0. RESULTS: CPKDP program was adapted for drugs with different characteristics of pharmacokinetics, and for single dose or multiple dose administration. Using 1 or 2 measured drug concentrations, individual patient's pharmacokinetic parameters were estimated based on population-average pharm-acokinetic parameters. CONCLUSION: CPKDP program is applied for estimating pharmacokinetic parameters and optimizing drug therapy in individual patients.��
Keywords�� individualizing drug dosage,   clinical pharmacokinetics,   computer program      
�ո�����: 1997-02-12;
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.�ٴ�ҩ��ѧ��ҩ���廯ϵͳ�����Ƽ�Ӧ��[J]  �й�ҩѧ��־, 1998,V33(04): 229-232
.Development and application clinical pharmacokinetics and individualizing dosage regimens system [J]  Chinese Pharmaceutical Journal, 1998,V33(04): 229-232
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