Abstract��
OBJECTIVE To establish a method for determination of fenofibric acid in rabbits plasma. METHODS Methanol-0.02mol��L-1 acetate salt buffer pH 3.6 (63��37) as mobile phase, indomethacin as internal standard,the wavelength of detection was 296nm. RESULTS The retention time of fenofibric acid and indomethacin was 3.80 and 6.56 min respectively. The intraday mean recovery of three different concentration of fenofibric acid were 97.02% (RSD=1.41%), 97.66% (RSD=4.27%) and 101.17 (RSD=1.01%)respectively, while the interday average recovery were 96.32% (RSD=4.91%),93.51 % (RSD=4.70%) and 95.60% (RSD =3.46%) in turn. CONCLUSIONS This method is sensitive with constant result and rapid for determining fenofibric acid concentration in rabbits plasma.
2002, Vol. 22 