Abstract��
OBJECTIVE To explore the brain function improving mechanism of ��Jiawei Wendan��(JWWD) prescription. METHODS By using high performance liquid chromatography to observe the change of 4 amino acids of SAM-P/10��s brain, which had close relation with learning memory.RESULTS The Glu, Gln��Asp in cortex of preventive prescription and prescription No. I decreased significantly��P0.01��, as to prescription NO.II, only Asp decreased obviously��P0.05��, all index of western medicine had no obvious reducing tendency. Asp in hippocampus of groups treated by Chinese medicine deceased significantly��P0.01��, so did western medicine��P0.05��, the level of Asn decreased after treatment, preventive prescription had no obvious difference from that of SAM-R/1,the increasing of the other groups��Asn had obvious difference from that of SAM-R/1��P0.01��,the Asp, Asn in striate body for preventive prescription and prescription No 1 droped obviously (P0.01), as to prescription No.��, only Asp, Asn has obviousy reduced, furthermore, decreasing of Asn is very different from that of SAM-R/1��P0.05��. The increasing of Glu, Asp, Asn in striate body treated by western medicine increased obviously (P0.01), Asp decreased obviously��P0.05��, but not so much as Chinese medicine.CONCLUSIONS It prompts that Jiawai Wendan prescription can regulate the level of SAM-P/10��s EAAs obviously. This provide bases for the clinical use of ��Jiawei Wendan�� prescription on the encephalic senility and senile dementia.
WANG Ping,
LIU Ling,
SHI Xue-Min etc
.The influence of Jiawei Wendan prescription on EAAs in hippocampi, cortex and striate body of brain of SAM-P/10[J] Chinese Pharmaceutical Journal, 2002,V22(11): 645-648
2002, Vol. 22 
