Abstract��
OBJECTIVE:The pharmacokinetics of ganciclovir was investigated in rabbits. METHODS:The serum urine and tissues level of ganciclovir was determined by high performance liquid chromatography. RESULTS:The pharmacokinetics of ganciclovir fitted to a three compartment model after iv of 5,10,20 mg/kg ganciclovir respectively. The mean values for maximum concentration of drug in serum were 20, 39��89 pg/ml. The eliminative half-life was 1.7h(1.4~1.8 h). The AUC was 12.94,25.35 and 40.0(pg��h)/ml after iv injection. The distribution of ganciclovir was wide. The level of drug in kidney was higher. We also recovered 90.8% (16.3%)of the administered ganciclovir from the urine as unchanged drug within 24 hours. CONCLUSION;The elimination of Ganciclovir was quickly in rabbits. There is no significant culmulation.
1996, Vol. 31 
