目的 研究乙酰胡椒乙胺(PAA)对小鼠化学中毒性肝损伤的保护作用。方法 小鼠ig PAA后ip四氯化碳(CCl₄)或D-氨基半乳糖(D-Gal)，检测肝损害的几项指标和肝脏的病理损害。结果 PAA可明显降低CCl₄，D-Gal引起的ALT升高，防止肝糖原下降，明显抑制由CCl₄体外引起的大鼠肝微粒体脂质过氧化。结论 PAA对CCl₄及D-Gal引起的肝损伤有明显保护作用。

OBJECTIVE To study the protective effects of piperoethyl acetyl amine (PAA) on hepatotoxin induced liver injury in mice. METHODS Those mice were treated with a dose of PAA 1 h before or two doses of PAA 24 h before in injection of CCl₄or D-galactosamine.Serum transaminase (ALT) and liver glycogen were determined.The damage of liver tissues was observed by light microscope.Malondialdehyde (MDA) production of liver microsomes initiated by CCl₄in vitro was measured. RESULTS Administration of PAA prior to CCl 4 significantly prevented the elevation of serum ALT and the decrease of liver glycogen in CCl4 or D-galactosamine intoxicated mice.The damage of liver tissues was also reduced.CCl₄initiated lipid peroxidation (MDA formation) of liver microsomes in vitro was inhibited by PAA in a dose-dependent manner. CONCLUSION The hepatoprotective action of PAA against CCl₄and D-galactosamine intoxication in mice may be related to its inhibitory effect on CCl₄initiated microsomal lipid peroxidation and the increase of liver glycogen.