Abstract��
OBJECTIVE:To determine the concentrations of fluorouracilum in serum, lungs and tumour in patients was lung cancer after inhaling fluorouracilum by ultrasonic atomizer, and check the method against the conventional methods. METHODS: 10 patients with lung cancer served as targets of the experiment. A high performance liquid chromatography method with a 5 ��m Kromasil C18column 4.6 mm��200 mm and a mobile phase consisted of acetonitrile��mthanol 0.025 mol��L-1K2HPO4solution (10��40��50) was used. After fluorour��acilum inhaled 250 mg: 10 ml, serum samples were collected at 2, 5, 10, 20, 30, 45, 60, 90, 120, 240 min and tissue samples obtained duing operation. The data obtained were fitted with PKBP��N1 pharmacokinetic progarm on a computer. RESULTS: The results showed that the disposion of fluorouracilum was conformed to a two��compartment model with t<>1/2Ka=0.10 h,t1/2��=0.15 h, t1/2��=0.34 h, tmax=0.23 h and cmax=2.32 ��g��mlmax. The concentration of tissue of lung and tumour was 0.37 ��g��g-1and 0.44 ��g��g-1. CONCLUSIONS: The assimilate rate for fluorouracilum is fast and the harmful effects are less and light with the inhaling fluorouracilum by ultrasonic atomizer rather than old preparation.
.Pharmacokinetic of inhaling fluorouracilum by ultrasonic atomizer and the concentration in lungs and tumour in patients with lung cancer[J] Chinese Pharmaceutical Journal, 1998,V33(01): 33-36
1998, Vol. 33 
