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�й�ҩѧ��־ 1998, Vol. 33 Issue (01) :25-29    DOI:
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�һ���ά����Ϊ���²����ڻ������ᱽ��������֬�ϵ�Ӧ��
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�Ϻ� 200437 �Ϻ�ҽҩ��ҵ�о�Ժ
Chen Qinghua
(Chen QH), Qu Wen (Qu W), Wen Ping (Wen P

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ժҪ Ŀ�ģ�����Ӱ��ҩ��֬�����ܳ������أ��Ʊ��������ᱽ������(PPA��HCl)��֬���������Բ�ͬճ�ȹ����һ���ά��(EC)Ϊ����Ĥ�����Ʊ�����PPA��HCl��֬���������ܳ����飬��������֬������ECճ�ȡ�EC�������ذٷ��ʡ�EC��ɢ����(ˮ���Ҵ�)�Լ������ͷŽ��ʵ�pHֵ������ǿ�ȶ���������ҩ��֬�����ܳ���Ӱ�졣������������ض�ҩ��֬����ҩ���в�ͬ�̶ȵ�Ӱ�죬��EC 200 Pa��s�������ش�150 g��kg-1ʱ������ҩ��֬��0.1 mol��L-1HCl�е��ͷŷ�������ҩ��23�滺��PPA��HCl���ҵ�Ҫ�󡣽��ۣ����һ���ά��Ϊ����Ĥ���ϣ������Ʊ�����PPA��HCl��֬��
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Abstract�� OBJECTIVE:To prepare sustained phenylpropanolamine��HCl (PPA��HCl)��resin complexes and to study the factors influencing the in vitro dissolution of it. METHOD : The sustained PPA��HCl��resin complexes were prepared by coating the complexes with different kinds of ethylcellulose (EC) as coating membranes. The factors influencing the release rate of PPA��HCl from the complexes, such as resin particle size, the viscosity and thickness of coating membrane, the dispersion medium of EC (water or alcohol) as well as the Ph and ion strength of dissolution medium were studied in detail. RESULTS: The factors above all influenced the dissolution of the complexes to different extent. When prepared by EC 200 Pa��s (150 g��kg-1), the dissolution of the coated complexes in 0.1 mol��L-1HCl accorded with the requirements of sustained PPA��HCl capsules of USP ������. CONCLUSION: The sustained PPA��HCl can be prepared by coating the drug resin complexes with EC.
Keywords�� phenylpropanolamine��HCl,   resin,   ethylcellulose,   coating,   sustained��release,   in vitro dissolution     
�ո�����: 1997-02-12;
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.�һ���ά����Ϊ���²����ڻ������ᱽ��������֬�ϵ�Ӧ��[J]  �й�ҩѧ��־, 1998,V33(01): 25-29
.Ethylcellulose as sustained release coating membrane of phenylpropanolamine��HCl resin complexes[J]  Chinese Pharmaceutical Journal, 1998,V33(01): 25-29
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