Abstract��
OBJECTIVE: To observe the duration and mechanism of action and effect of nafarelin(Naf ) depot formulation on pituitary function in the rat. METHODS: A modified RICT(the rat interstitial cell testosterone) assay was used to determine serum bioactive LH levels of rats. RESULTS: The duration of action of Naf depot formulation in vivo was (40.0��6.8) d. The peak concentrations of serum LH levels in the estrous cycle and in the responses to an acute LHRH agonist challenge were suppressed significantly in the Naf depot formulation-treated rats. No changes in serum LH levels before and after ovariectomy were observed in the rat previously treated with Naf depot formulation 2 weeks before ovariectomy. CONCLUSION: The long action of domestic Naf depot formulation is certain. The pituitary function of rats was suppressed directly and significantly 3 weeks after treatment with a single administration of Naf depot formulation.
1997, Vol. 32 
