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�й�ҩѧ��־ 2009, Vol. 44 Issue (14) :1080-1083    DOI:
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�Ϸʹ�ҵ��ѧ��ҩ����ϵ �Ϸ� 230009
ZHANG Xiao-xiang��ZHU Mei-mei��ZHENG Shan-shan
Department of Pharmaceutical Engineering, Hefei University of Technology, Hefei 230009, China

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ժҪ Ŀ���о��������򱽼�����(secnidazole benzoate,SBZ)���DZ���-��-������(hydroxylpropyl-��-cyclodextrin,HP-��-CD)��ˮ��Һ�еİ������á����ϱȼ����Ϲ����е�����ѧ�����仯�������ֱ�������ܽ�ȷ����������շֹ��ȷ�����Ħ��ϵ�з��ȷ����ⶨSBZ��HP-��-CD��ˮ��Һ�а������á����ϱȼ����Ϲ����е�����ѧ�����仯������ڲ�ͬpHֵ�Ļ���Һ��,SBZ��HP-��-CD�����γ�1��1������;����ѧ������ʾ���Ϲ���Ϊ���ƶ����ؼ�����,���Է�����(��G<0)������SBZ��HP-��-CD��ˮ��Һ�п��Է��γ�Ħ����Ϊ1��1�İ�����,�Ӷ��������ܽ�ȡ�ѡ�����˵İ����¶ȼ����ʵ�pHֵ�������ڰ��Ϲ��̵Ľ��С�
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Abstract�� OBJECTIVE To investigate the complexation of secnidazole benzoate with hydroxylpropyl-��-cyclodextrin (HP-��-CD) in aqueous solutions, inclusion molar radio of the host to guest molecules and change of thermodynamic parameters during the complexation process. METHODS The complexation mechanism, inclusion molar ratio of the host to guest molesules and change of thermodynamic parameters were measured by phase solubility method, UV spectrophotometry, and equimolar series method, respectively. RESULTS The 1��1 molar ratio inclusion complex was obtained in various pH buffered solutions. The inclusion process was induced automatically along with the release of heat and the decrease of entropy. CONCLUSION An 1��1 molar ratio inclusion complex of secnidazole benzoate with HP-��-CD could be formed spontaneously. The solubility of secnidazole benzoate in aqueous solution was increased. Appropriate temperature and suitable media pH probably favor the progress of the inclusion process.
Keywords�� secnidazole benzoute,   hydroxylpropyl-��-cyclodextrin,   complexation ratio,   complexation,   thermodynamic parameter      
�ո�����: 2008-11-22;
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.�������򱽼��������DZ���-��-��������ˮ��Һ�а������õ��о�[J]  �й�ҩѧ��־, 2009,V44(14): 1080-1083
.Study on the Complexation of Secnidazole Benzoate with Hydroxylpropyl-��-Cyclodextrin in Aqueous Solution [J]  Chinese Pharmaceutical Journal, 2009,V44(14): 1080-1083
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