Abstract��
In order to avoid high initial peak of the commercially available indomethacinformulations and increase the interval between dosages,controlled release capsule contahingindomethacin pellets,coated with polymethacrylates,were prepared by using fluidized bed coatedtechnique.Each capsule contained 75mg indomethacin,and was taken once a day. The in vitrodissolution and in vivo bioavilability(in 12 human subjects)of the capsule were determined andcompared.Determination of indomethacin serum comcentral was capsule out by HPLC.The studies showed the capsule relese drug with a first-order kinetics in vitro(Kr=0.2266h-1)and demonsteatad a smoother serum concentration-time profile than a conventional capsule in elimination phase but much lower in macximum concentration in vivo.There was a linear relationship between percent absorption in vivo and percent dissolition in vitro(r=0.9901.P��0.01).Bioavailability of the controlled release was also better than that of the concentional capsule.
1994, Vol. 29 
