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�й�ҩѧ��־ 2009, Vol. 44 Issue (07) :498-501    DOI:
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ZHENG Bao-ying1��ZHANG Jie1*��MA Yue2��LI Jing-yun2
1. Department of Respiratory Medicine, Beijing Tian Tan Hospital, Capital Medical University��Beijing 100050��China��2. Department of Antibiotics, National Institute for the Control of Pharmaceutical and Biological Products��Beijing 100050��China

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Abstract�� OBJECTIVE To investigate the combination of penicillin and azithromycin against Streptococcus pneumoniae in vitro and in vivo and then to guide clinical medication. METHODS Three isolates of S. pneumoniae 6305, 2000099-1 and ATCC 49619 were used in vitro. FIC indices were calculated by the chequerboard method to evaluate the interactions between penicillin and azithromycin against three isolates of S. pneumoniae. S. pneumoniae 2000099-1 which was susceptible to both penicillin and azithromycin was used in vivo. Swiss mice were infected by the intratracheal route with 30 ��L of bacterial suspension. The time-kill curves of groups with different medication were obtained for the evaluation of antibiotic interactions. RESULTS The FIC index of three isolates were 1-2, and the combination was independent in vitro. The decrease of <2 lgCFU��mL-1 of bacterial densities in the lungs was found in the combination group, compared with the group treated with the most effective agent used alone in vivo. The combination was considered as independent. CONCLUSION The combination of penicillin and azithromycin showed independent both in vitro and in vivo, this medication could be used for initial empirical treatment in community-acquired pneumonia.
Keywords�� penicillin,   azithromycin,   drug combination,   Streptococcus pneumoniae     
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֣��Ӣ, �Ž�, ��Խ�� .��ù���밢��ù������Ӧ�öԷ����������Ч���о�[J]  �й�ҩѧ��־, 2009,V44(07): 498-501
ZHENG Bao-ying, ZHANG Jie, MA Yue etc .Combination of Penicillin and Azithromycin Against Streptococcus pneumoniae in Vitro and in Vivo[J]  Chinese Pharmaceutical Journal, 2009,V44(07): 498-501
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