氮芥类抗肿瘤药物研究进展

庄雅云;周成合;王渝芳;李东红

中国药学杂志 ›› 2008, Vol. 43 ›› Issue (17) : 1281-1287.

中国药学杂志 ›› 2008, Vol. 43 ›› Issue (17) : 1281-1287.
综述

氮芥类抗肿瘤药物研究进展

  • 庄雅云;周成合;王渝芳;李东红
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文章历史 +

摘要

目的综述氮芥类化合物在抗肿瘤方面的研究进展。方法依据近年国内外文献阐述脂肪氮芥、芳基氮芥、芳烷基氮芥、大环类氮芥、磷酰胺氮芥和金属配合物氮芥等的抗肿瘤活性,并且简述了氮芥的抗肿瘤机制。结果与结论氮芥类化合物在治疗肿瘤方面发挥了重要作用,是目前研究开发的热点领域之一,随着研究的不断深入,将有越来越多的高效、低毒的氮芥类抗肿瘤药物用于临床。

关键词

氮芥 / 抗肿瘤 / 抗癌 / 环磷酰胺 / 大环 / 金属配合物

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导出引用
庄雅云;周成合;王渝芳;李东红. 氮芥类抗肿瘤药物研究进展[J]. 中国药学杂志, 2008, 43(17): 1281-1287

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基金

重庆市自然科学基金(CSTC,2007BB5369);西南大学基金(XSGX0602,SWUB2006018,SWUF2007023)

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