酪氨酸激酶抑制剂的研究进展

史爱新;傅得兴

中国药学杂志 ›› 2008, Vol. 43 ›› Issue (14) : 1045-1049.

中国药学杂志 ›› 2008, Vol. 43 ›› Issue (14) : 1045-1049.
综述

酪氨酸激酶抑制剂的研究进展

  • 史爱新;傅得兴
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摘要

目的综述多靶点受体酪氨酸激酶抑制剂(RTKIs)的最新研究进展及有关临床评价。方法查阅国内外文献,归纳目前多靶点受体酪氨酸激酶抑制剂的作用特点及临床评价。结果受体酪氨酸激酶(RTKs)的过度表达,与多种肿瘤的发生、发展及转移相关。抑制RTKs的活性就可有效地抑制肿瘤。随着RTKs研究发展,已开发了多种受体RTKIs,并对多种肿瘤的治疗取得了令人鼓舞的疗效。RTKIs分为单靶点和多靶点酪氨酸激酶抑制剂。结论多靶点RTKIs抗肿瘤的机制包括抑制血管生成、对肿瘤细胞存活和增殖时造成的多个酪氨酸激酶受体异常水平进行调控,是肿瘤治疗药物的发展方向之一。

关键词

多靶点 / 受体酪氨酸激酶抑制剂 / 抗肿瘤作用

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史爱新;傅得兴. 酪氨酸激酶抑制剂的研究进展[J]. 中国药学杂志, 2008, 43(14): 1045-1049

参考文献

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