中国药学杂志
    
           首页  |  期刊介绍  |  编 委 会  |  投稿指南  |  期刊订阅  |  广告服务  |  会议信息  |  联系我们  | 
�й�ҩѧ��־ 2008, Vol. 43 Issue (07) :544-550    DOI:
���� ����Ŀ¼ | ����Ŀ¼ | ������� | �߼����� << | >>
������佺��Һ��ɫ������-�������࿹���ض�������-���Թ�ϵԤ��ģ�͵��о�
����Ƽ;������;����;�´�;�����;Ҷ����
1.�Ĵ���ѧ����ҩѧԺ �ɶ� 610041;2.����ҽѧԺ����ҽԺ �Ĵ� ���� 646000;3.�Ĵ���ѧ����ҽԺ �ɶ� 610041
WU Li-ping1�� WANG Shu-rong2�� CHEN Yu3�� CHEN Cong1�� WU Jia-qi1�� YE Li-ming1
1. West China School of Pharmacy�� Sichuan University�� Chengdu 610041�� China�� 2.Affiliated Hospital of Luzhou Medical College�� Luzhou 646000�� China��3. West China Hospital�� Sichuan University�� Chengdu 610041�� China

Download: PDF (0KB)   HTML (0KB)   Export: BibTeX or EndNote (RIS)      Supporting Info
ժҪ Ŀ������������佺��Һ��ɫ��(BMC)��������-�������࿹����ijЩҩ��ѧ���ʾ���Ԥ�������Ķ�������-���Թ�ϵ(QRAR)ģ�͡�����ͨ����ˮ����ϵ��(logP)�о�BMC��Brij35��Ũ��,�����Ż���ɫ�����������ⶨģ��ҩ�����ʵ��������������(K)����������������Բ���,��������������,������������QRARģ��,����ģ�ͽ����������ۡ����AUC��t1/2��,t1/2����F%��QRARģ�������Ŷ�95%��ˮƽ����ͳ��ѧ����(P<0.05),ģ��Ԥ���������š�Lag-T����max��QRARģ���ڴ�����ˮƽ����ͳ��ѧ���塣����ʹ�õ�һ����(K)��Ԥ����-��������ҩ��ijЩ��������ǿ��е�,QRARɫ��ģ����һ���о�ҩ��ѧ����Чģ�͡�
Service
�ѱ����Ƽ�������
�����ҵ����
�������ù�����
Email Alert
RSS
�����������
����Ƽ
������
����
�´�
�����
Ҷ����
����Ƽ
������
����
�´�
�����
Ҷ����
�ؼ����� ��������-���Թ�ϵģ��   ������佺��Һ��ɫ��   ��-�������࿹����     
Abstract�� OBJECTIVE To develop the quantitative retention-activity relationship(QRAR) models by biopartitioning micellar chromatography(BMC) for estimating the pharmacokinetic parameters of ��-lactam antibiotics.METHODS The n-octanol-water partition coefficient was used to obtain the better qualification of BMC system,then the retention of drug was detected and calculated.The models were established by software with bioactivity parameters of ��-lactam antibiotics in literatures and retention values in BMC,and the model predictive ability was evaluated according to RMSEC,RMSECV,and RMSECVi.RESULTS The QRAR models of AUC,t1/2��,t1/2��,and F% obtained in physiological conditions were statistically significant,while ��max and Lag-T models showed no significance.CONCLUSION The results indicate that,using only one descriptor(the retention factor,K) to explain the bioactivity of ��-lactam antibiotics is feasible,in vitro approach is an advanced tool for pharmacokinetic research of the drugs.
Keywords�� quantitative retention-activity relationship models,   biopartitioning micellar chromatography,   ��-lactam antibiotics      
�ո�����: 2007-04-17;
ͨѶ���� Ҷ����   
���ñ���:   
����Ƽ, ������, ����� .������佺��Һ��ɫ������-�������࿹���ض�������-���Թ�ϵԤ��ģ�͵��о�[J]  �й�ҩѧ��־, 2008,V43(07): 544-550
WU Li-ping, WANG Shu-rong, CHEN Yu etc .Study on Quantitative Retention-Activity Relationship Models of ��-Lactam Antibiotics by Biopartitioning Micellar Chromatography [J]  Chinese Pharmaceutical Journal, 2008,V43(07): 544-550
��
û�б��IJο�����
û���ҵ������������
Copyright 2010 by �й�ҩѧ��־