OBJECTIVE To investigate the pharmacokinetics of ibuprofen eugenol ester microemulsion(IEE-ME) in rats.METHODS The protective effect of IEE-ME and ibuprofen on ulcer was assessed pathologically in mice.Following the oral administration of IEE-ME or ibuprofen solution into rats,the blood samples were collected at 0.5,1,2,3,4,5,6,8,10 and 12 h and the plasma ibuprofen concentration was then quantified by HPLC.RESULTS The IEE-ME decreased the ulcerogenic percent obviously.The pharmacokintic parameters of the IEE-IEE and the solution were followed as:AUC0-12 were(270.31±58.32) and(55.07±39.77) mg·h·L-1,ρmax(64.6±10.34) and(39.94±9.72) mg·L-1,tmax 1 and 1 h,MRT0-12(3.69±0.06) and(3.62±0.54)h,respectively.CONCLUSION IEE-ME can decrease ulcerogenic probability induced by ibuprofen,and enhance the bioavailability of ibuprofen after oral IEE-ME.
ZHO Xiu-li;CHEN D-wei;HU Hi-yng;QIO Ming-xi.
Study on Pharmacokinetics of Oral Ibuprofen Eugenol Ester Microemulsion in Rats [J]. Chinese Pharmaceutical Journal, 2008, 43(07): 532-534
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